Anti-TNF therapy and malignancy - A critical review

被引：33

作者：

Cohen, RB ^{[1
]}

Dittrich, KA ^{[1
]}

机构：

[1] Fox Chase Canc Ctr, Dept Med Oncol, Philadelphia, PA 19111 USA

来源：

CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY | 2001年 / 15卷 / 06期

关键词：

anti-tumour necrosis factor; cancer; Crohn's disease; etanercept; infliximab; lymphoma; malignancy; rheumatoid arthritis;

D O I：

10.1155/2001/403102

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The roles of tumour necrosis factor (TNF) and anti-TNF ther apy in malignancy are reviewed, including an overview of baseline risk factors for malignancy in inflammatory diseases and the incidences of malignancies observed in clinical trials of an anti-TNF-alpha therapy, infliximab. The preclinical data and early clinical experience presented for infliximab do not provide evidence for a causal relationship between TNF a antagonism and the development of lymphoid or nonlymphoid cancers.

引用

页码：376 / 384

页数：9

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