Interactions of general anesthetics within the pore of an ion channel

被引：7

作者：

Barann, M

Wenningmann, I

Dilger, JP ^{[1
]}

机构：

[1] Univ Bonn, Anasthesiol Klin, D-53127 Bonn, Germany

[2] SUNY Stony Brook, Dept Anesthesiol, Stony Brook, NY 11794 USA

[3] SUNY Stony Brook, Dept Physiol & Biophys, Stony Brook, NY 11794 USA

来源：

TOXICOLOGY LETTERS | 1998年 / 101卷

关键词：

interaction; general anesthetics; ion channels; pore;

D O I：

10.1016/S0378-4274(98)00180-5

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

(1) We review the electrophysiological evidence that the ion channel pore is the site at which general anesthetics bind to inhibit muscle-type acetylcholine receptor channels. (2) The amphipathic character of a pore certainly offers a suitable environment for the binding of amphipathic anesthetics. (3) The absence of direct information about the binding sites of these rather non-specific drugs, forces us to rely on indirect information provided by kinetic experiments. (4) We also discuss the implications of these findings for the interaction of general anesthetics with other ion channels. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：155 / 161

页数：7

共 27 条

[1] VOLTAGE JUMP ANALYSIS OF PROCAINE ACTION AT FROG ENDPLATE [J].