Flavonoids: Potential Wnt/beta-catenin signaling modulators in cancer

被引：83

作者：

Amado, Nathalia G. ^{[1
]}

Fonseca, Barbara F. ^{[1
]}

Cerqueira, Debora M. ^{[1
]}

Neto, Vivaldo Moura ^{[1
]}

Abreu, Jose G. ^{[1
]}

机构：

[1] Univ Fed Rio de Janeiro, Inst Ciencias Biomed, BR-21949590 Rio De Janeiro, Brazil

来源：

LIFE SCIENCES | 2011年 / 89卷 / 15-16期

关键词：

Natural compounds; Wnt signaling pathway; Cancer; Isoquercitrin; Polyphenols; Small molecules; CELL-CYCLE ARREST; ENDOTHELIAL GROWTH-FACTOR; NF-KAPPA-B; GREEN TEA CATECHINS; PROTEIN-KINASE CK2; PROSTATE-CANCER; INDUCED APOPTOSIS; LUNG-CANCER; IN-VITRO; INHIBITS PROLIFERATION;

D O I：

10.1016/j.lfs.2011.05.003

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Flavonoids are polyphenolic compounds found throughout the plant kingdom. They occur in every organ but are usually concentrated in leaves and flowers. During the last two decades, in vitro and in vivo studies demonstrated that flavonoids have inhibitory effects on human diseases through targeting of multiple cellular signaling components. Wnt/beta-catenin signaling regulates proliferation, differentiation and fate specification in developmental stages and controls tissue homeostasis in adult life. For these reasons, this pathway has received great attention in the last years as potential pathway involved in distinct Human pathologies. In this review we discuss the emerging potential mechanisms for flavonoids on Wnt/beta-catenin signaling in cancer and possible investigation strategies to understand flavonoids mode of action on this signaling pathway. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：545 / 554

页数：10

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