Effect of gentamicin dosing interval on efficacy of penicillin or ceftriaxone treatment of experimental endocarditis due to penicillin-susceptible, ceftriaxone-tolerant viridans group streptococci

被引:5
作者
Brandt, CM
Warner, CB
Rouse, MS
Steckelberg, JM
Wilson, WR
机构
[1] MAYO CLIN & MAYO FDN,DIV INFECT DIS,ROCHESTER,MN 55905
[2] MAYO CLIN & MAYO FDN,INFECT DIS RES LAB,ROCHESTER,MN 55905
关键词
D O I
10.1128/AAC.40.12.2901
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The efficacy of ceftriaxone or penicillin alone or combined with gentamicin at different dosing intervals was evaluated in experimental endocarditis due to a penicillin-susceptible, ceftriaxone-tolerant strain of Streptococcus sanguis I. The difference between monotherapy with ceftriaxone and procaine penicillin approached statistical significance (P = 0.052). Ceftriaxone combined with gentamicin administered as a single daily dose was less effective than was procaine penicillin combined with gentamicin administered in a single daily dose or in three divided doses.
引用
收藏
页码:2901 / 2903
页数:3
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