Biomarkers for systemic lupus erythematosus: a review and perspective

被引:48
作者
Liu, CC
Manzi, S
Ahearn, JM
机构
[1] Univ Pittsburgh, Sch Med, Div Clin Immunol & Rheumatol, Pittsburgh, PA 15261 USA
[2] Univ Pittsburgh, Sch Hlth Sci, Lupus Ctr Excellence, Pittsburgh, PA 15261 USA
[3] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA 15213 USA
关键词
biomarker; disease activity; systemic lupus erythematosus;
D O I
10.1097/01.bor.0000174182.70159.22
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Purpose of review Despite decades of extensive work in the understanding of the etiopathogenesis of systemic lupus erythematosus, few biomarkers have been validated and widely accepted for this disease. The lack of reliable, specific biomarkers not only hampers clinical management of systemic lupus erythematosus but also impedes development of new therapeutic agents. This paper reviews briefly the historical aspects of systemic lupus erythematosus biomarkers and summarizes recent studies on candidate biomarkers. Recent findings Recognizing the urgent need for lupus biomarkers, a Lupus Biomarker Working Group has recently been initiated to facilitate collaborative efforts aimed at identifying and validating biomarkers for systemic lupus erythematosus. Based on available data, several laboratory markers have shown promise as biomarkers for susceptibility, diagnosis, and disease activity. These include Fc receptor genes (disease susceptibility), complement C4d-bound erythrocytes (diagnosis or disease activity), CD27(high) plasma cells (disease activity), 'interferon signature' (disease activity), and anti-C1q antibodies (disease activity and organ involvement). Summary There is a longstanding and recently rejuvenated enthusiasm for biomarkers that precisely and specifically, reflect the pathophysiologic and clinical changes in systemic lupus erythematosus. Promising candidate biomarkers have been identified but must still be validated through rigorous, large-scale multicenter studies.
引用
收藏
页码:543 / 549
页数:7
相关论文
共 89 条
  • [1] Development of autoantibodies before the clinical onset of systemic lupus erythematosus
    Arbuckle, MR
    McClain, MT
    Rubertone, MV
    Scofield, RH
    Dennis, GJ
    James, JA
    Harley, JB
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2003, 349 (16) : 1526 - 1533
  • [2] Increased frequency of pre-germinal center B cells and plasma cell precursors in the blood of children with systemic lupus erythematosus
    Arce, E
    Jackson, DG
    Gill, MA
    Bennett, LB
    Banchereau, J
    Pascual, V
    [J]. JOURNAL OF IMMUNOLOGY, 2001, 167 (04) : 2361 - 2369
  • [3] Biomarkers and surrogate endpoints: Preferred definitions and conceptual framework
    Atkinson, AJ
    Colburn, WA
    DeGruttola, VG
    DeMets, DL
    Downing, GJ
    Hoth, DF
    Oates, JA
    Peck, CC
    Schooley, RT
    Spilker, BA
    Woodcock, J
    Zeger, SL
    [J]. CLINICAL PHARMACOLOGY & THERAPEUTICS, 2001, 69 (03) : 89 - 95
  • [4] Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus
    Baechler, EC
    Batliwalla, FM
    Karypis, G
    Gaffney, PM
    Ortmann, WA
    Espe, KJ
    Shark, KB
    Grande, WJ
    Hughes, KM
    Kapur, V
    Gregersen, PK
    Behrens, TW
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (05) : 2610 - 2615
  • [5] The emerging role of interferon in human systemic lupus erythematosus
    Baechler, EC
    Gregersen, PK
    Behrens, TI
    [J]. CURRENT OPINION IN IMMUNOLOGY, 2004, 16 (06) : 801 - 807
  • [6] Rheumatic syndromes associated with complement deficiency
    Barilla-LaBarca, ML
    Atkinson, JP
    [J]. CURRENT OPINION IN RHEUMATOLOGY, 2003, 15 (01) : 55 - 60
  • [7] Activation of type I interferon system in systemic lupus erythematosus correlates with disease activity but not with antiretroviral antibodies
    Bengtsson, AA
    Sturfelt, G
    Truedsson, L
    Blomberg, J
    Alm, G
    Vallin, H
    Rönnblom, L
    [J]. LUPUS, 2000, 9 (09) : 664 - 671
  • [8] Interferon and granulopoiesis signatures in systemic lupus erythematosus blood
    Bennett, L
    Palucka, AK
    Arce, E
    Cantrell, V
    Borvak, J
    Banchereau, J
    Pascual, V
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 197 (06) : 711 - 723
  • [9] The relationship between serum ferritin levels and disease activity in systemic lupus erythematosus
    Beyan, E
    Beyan, C
    Demirezer, A
    Ertugrul, E
    Uzuner, A
    [J]. SCANDINAVIAN JOURNAL OF RHEUMATOLOGY, 2003, 32 (04) : 225 - 228
  • [10] DERIVATION OF THE SLEDAI - A DISEASE-ACTIVITY INDEX FOR LUPUS PATIENTS
    BOMBARDIER, C
    GLADMAN, DD
    UROWITZ, MB
    CARON, D
    CHANG, CH
    [J]. ARTHRITIS AND RHEUMATISM, 1992, 35 (06): : 630 - 640