Lamotrigine may limit pathological excitation in the hippocampus by modulating a transient potassium outward current

被引：40

作者：

Grunze, H

Greene, RW

Möller, HJ

Meyer, T

Walden, J

机构：

[1] Univ Munich, Psychiat Klin, D-80336 Munich, Germany

[2] Harvard Univ, Sch Med, Brockton, MA 02401 USA

[3] Vet Adm Med Ctr, Brockton, MA 02401 USA

[4] Univ Freiburg, Klin Psychiat & Psychosomat, D-79104 Freiburg, Germany

来源：

BRAIN RESEARCH | 1998年 / 791卷 / 1-2期

关键词：

lamotrigine; epilepsy; bipolar affective disorder; hippocampus; potassium current;

D O I：

10.1016/S0006-8993(98)00180-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Actions of the new antiepileptic drug lamotrigine were characterised using whole cell patch clamp recordings from rat CA1 pyramidal cells in vitro. The results suggest that lamotrigine, besides its previously described effect on the fast sodium inward current and calcium currents, modulates the transient potassium outward current I-D. This may be an effective mechanism to inhibit pathological excitation. (C) 1998 Elsevier Science B.V.

引用

页码：330 / 334

页数：5

共 11 条

[1] WHOLE CELL RECORDING FROM NEURONS IN SLICES OF REPTILIAN AND MAMMALIAN CEREBRAL-CORTEX [J].