The thought-translation device (TTD):: Neurobehavioral mechanisms and clinical outcome

被引：93

作者：

Birbaumer, N ^{[1
]}

Hinterberger, T

Kübler, A

Neumann, N

机构：

[1] Univ Tubingen, Inst Med Psychol & Behav Neurobiol, D-72074 Tubingen, Germany

[2] Univ Trent, Ctr Cognit Neurosci, I-38100 Trento, Italy

[3] Univ Dublin Trinity Coll, Dept Psychol, Dublin 2, Ireland

来源：

IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING | 2003年 / 11卷 / 02期

关键词：

amyotrophic lateral sclerosis (ALS); locked-in-syndrome; physiological brain regulation; slow cortical potentials;

D O I：

10.1109/TNSRE.2003.814439

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The thought-translation device (TTD) consists of a training device and spelling program for the completely paralyzed using slow-cortical brain potentials (SCP). During the training phase, the. self-regulation of. SCPs is learned through visual-auditory feedback and positive reinforcement of SCPs; during the spelling phase, patients select letters or words with their SCPs. A psychophysiological system for detection of cognitive functioning in completely paralyzed patients is an integral part of the TTD. The neurophysiological and anatomical basis of SCP-regulation was investigated by recording of BOLD-response in functional magnetic resonance imaging. Results showed involvement of basal ganglia and premotor cortex for required SCP positivity. The clinical outcome of 11 paralyzed patients using the TTD and quality of life of severely-paralyzed patients is described. First. attempts to improve learning of brain regulation with transcranial magnetic stimulation were successful.

引用

页码：120 / 123

页数：4

共 33 条

[1]

[Anonymous], 1997, Skalen zur Erfassung der Lebensqualitat: SEL

[2]

BAUER H, 1998, GLIAL CELLS THEIR RO, P267

[3] SLOW POTENTIALS OF THE CEREBRAL-CORTEX AND BEHAVIOR [J].

BIRBAUMER, N ;

ELBERT, T ;

CANAVAN, AGM ;

ROCKSTROH, B .

PHYSIOLOGICAL REVIEWS, 1990, 70 (01) :1-41

[4] Slow cortical potentials: Plasticity, operant control, and behavioral effects [J].

Birbaumer, N .

NEUROSCIENTIST, 1999, 5 (02) :74-78

[5] A spelling device for the paralysed [J].

Birbaumer, N ;

Ghanayim, N ;

Hinterberger, T ;

Iversen, I ;

Kotchoubey, B ;

Kübler, A ;

Perelmouter, J ;

Taub, E ;

Flor, H .

NATURE, 1999, 398 (6725) :297-298

[6] SLOW BRAIN POTENTIALS, IMAGERY AND HEMISPHERIC-DIFFERENCES [J].

BIRBAUMER, N ;

LANG, PJ ;

COOK, E ;

ELBERT, T ;

LUTZENBERGER, W ;

ROCKSTROH, B .

INTERNATIONAL JOURNAL OF NEUROSCIENCE, 1988, 39 (1-2) :101-116

[7] The thought translation device (TTD) for completely paralyzed patients [J].

Birbaumer, N ;

Kübler, A ;

Ghanayim, N ;

Hinterberger, T ;

Perelmouter, J ;

Kaiser, J ;

Iversen, I ;

Kotchoubey, B ;

Neumann, N ;

Flor, H .

IEEE TRANSACTIONS ON REHABILITATION ENGINEERING, 2000, 8 (02) :190-193

[8] THE INFLUENCE OF LOW-LEVEL TRANSCORTICAL DC-CURRENTS ON RESPONSE SPEED IN HUMANS [J].

ELBERT, T ;

LUTZENBERGER, W ;

ROCKSTROH, B ;

BIRBAUMER, N .

INTERNATIONAL JOURNAL OF NEUROSCIENCE, 1981, 14 (1-2) :101-114

[9] Theoretical and computational analysis of skill learning, repetition priming, and procedural memory [J].

Gupta, P ;

Cohen, NJ .

PSYCHOLOGICAL REVIEW, 2002, 109 (02) :401-448

[10]

HINTERBERGER T, IN PRESS EXP BRAIN R

← 1 2 3 4 →