Adipose tissue as an active endocrine organ: recent advances

被引：133

作者：

Gimeno, RE ^{[1
]}

Klaman, LD ^{[1
]}

机构：

[1] Wyeth Ayerst Res, Dept Cardiovasc & Metab Dis, Cambridge, MA 02140 USA

来源：

CURRENT OPINION IN PHARMACOLOGY | 2005年 / 5卷 / 02期

关键词：

D O I：

10.1016/j.coph.2005.01.006

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Adipose tissue secretes a variety of factors in a manner dependent upon its metabolic state. These factors are derived from adipocyte or non-adipocyte fractions, and include proteins, metabolites and hormones. Obesity is a major risk factor for type 2 diabetes and cardiovascular disease, and adipocyte-derived factors might contribute to or ameliorate obesity-associated pathologies such as insulin resistance, dyslipidemia, vascular dysfunction and a chronic inflammatory and prothrombotic state.

引用

页码：122 / 128

页数：7

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