Silymarin inhibits TNF-α-induced expression of adhesion molecules in human umbilical vein endothelial cells

被引：40

作者：

Kang, JS

Park, SK

Yang, KH

Kim, HM ^{[1
]}

机构：

[1] Korea Res Inst Biosci & Biotechnol, Biopotency Evaluat Lab, Taejon 305333, South Korea

[2] Korea Adv Inst Sci & Technol, Dept Biol Sci, Taejon 305701, South Korea

来源：

FEBS LETTERS | 2003年 / 550卷 / 1-3期

关键词：

silymarin; VCAM-1; ICAM-1; E-selectin; NF-kappa B/Rel;

D O I：

10.1016/S0014-5793(03)00827-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Silymarin is known to have an anti-atherosclerotic activity, but the mechanism responsible for it remains unclear. Here, we demonstrate a possible mechanism involved in the anti-atherosclerotic activity of silymarin. Silymarin inhibited THP-1 cell adhesion to human umbilical vein endothelial cells (HUVECs). Silymarin also suppressed the TNF-alpha-induced protein and mRNA expression of adhesion molecules, such as VCAM-1, ICAM-1 and E-selectin, in HUVECs. Moreover, silymarin suppressed the TNF-alpha-induced DNA binding of NF-kappaB/Rel in HUVECs. Taken together, these results demonstrate that silymarin exerts an anti-atherosclerotic activity, at least in part, by inhibiting the expression of adhesion molecules. (C) 2003 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.

引用

页码：89 / 93

页数：5

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