Negative association between T102C polymorphism of the 5-HT2a receptor gene and schizophrenia in Japan

被引：35

作者：

Shinkai, T ^{[1
]}

Ohmori, O ^{[1
]}

Kojima, H ^{[1
]}

Terao, T ^{[1
]}

Suzuki, T ^{[1
]}

Abe, K ^{[1
]}

机构：

[1] Univ Occupat & Environm Hlth, Sch Med, Dept Psychiat, Yahatanishi Ku, Kitakyushu, Fukuoka 807, Japan

来源：

HUMAN HEREDITY | 1998年 / 48卷 / 04期

关键词：

schizophrenia; 5-HT2a receptor; polymorphism; chromosome; 13;

D O I：

10.1159/000022803

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Serotonin (5-hydroxvtryptamine, 5-HT) may play an important role in the pathogenesis of schizophrenia. Previous studies suggested that the efficacy of atypical neuroleptic drugs (e,g., risperidone and clozapine) on negative symptoms may be related to the 5-HT2a receptor. Although association studies between MspI polymorphism (T102C) and the 5-HT2a receptor gene and schizophrenia have been reported, their results are still controversial. The aim of this study was to examine the association between T102C polymorphism of the 5-HT2a receptor gene and schizophrenia as well as the association between the polymorphism and negative symptoms in a Japanese population (106 patients with schizophrenia and 109 healthy controls). No significant positive associations were observed. Our results suggest that the 5-HT2a receptor gene is not involved in the pathogenesis of schizophrenia or negative symptoms.

引用

页码：212 / 215

页数：4

共 16 条

[1]

BURNET PWJ, 1995, LANCET, V346, P909

[2] Systematic screening for mutations in the human serotonin-2A (5-HT2A) receptor gene: Identification of two naturally occurring receptor variants and association analysis in schizophrenia [J].