Cutting edge: Is vasoactive intestinal peptide a type 2 cytokine?

被引：78

作者：

Delgado, M

Ganea, D

机构：

[1] Rutgers State Univ, Dept Biol Sci, Newark, NJ 07102 USA

[2] Univ Complutense, Fac Biol, Dept Biol Celular, E-28040 Madrid, Spain

来源：

JOURNAL OF IMMUNOLOGY | 2001年 / 166卷 / 05期

关键词：

D O I：

10.4049/jimmunol.166.5.2907

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A component of the chemical language shared by the immune and nervous system is the expression of neuropeptides by immune cells. Vasoactive intestinal peptide (VIP) was shown to be produced by T lymphocytes. Here me investigate whether T cell subsets differentially express VIP. Our studies indicate that, upon specific Ag stimulation, Th2 and T2 cells, but not Th1 and T1 cells derived from TCR transgenic (Tg) mice, express VIP mRNA and protein, and secrete VIP. Following immunization with the specific Ag, significant levels of VIP are present in the serum of syngeneic, non-Tg hosts that receive Th2, but not Th1 Tg cells. Th2 Tg cells recovered from the non-Tg hosts immunized with the specific Ag, but not with an irrelevant Ag, express intracellular VIP, Because VIP is produced by Ag-stimulated type 2 T cells, and differentially affects Th1 and Th2 cells, could VIP be viewed as a type 2 cytokine?

引用

页码：2907 / 2912

页数：6

共 30 条

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