Effect of the Pro12Ala variant of the human peroxisome proliferator-activated receptor γ2 gene on adiposity, fat distribution, and insulin sensitivity in Japanese men

被引:120
作者
Mori, Y
Kim-Motoyama, H
Katakura, T
Yasuda, K
Kadowaki, H
Beamer, BA
Shuldiner, AR
Akanuma, Y
Yazaki, Y
Kadowaki, T
机构
[1] Univ Tokyo, Fac Med, Dept Internal Med 3, Bunkyo Ku, Tokyo 113, Japan
[2] Asahi Life Fdn, Inst Diabet Care & Res, Tokyo, Japan
[3] Nippon Express Hlth Insurance Soc, Tokyo, Japan
[4] Chiba Univ, Fac Med, Dept Complex Dis, Chiba, Japan
[5] Johns Hopkins Univ, Div Geriatr Med & Gerontol, Baltimore, MD 21205 USA
[6] Univ Maryland, Sch Med, Div Diabet Obes & Nutr, Baltimore, MD 21201 USA
关键词
D O I
10.1006/bbrc.1998.9421
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
To examine the role of the Pro12Ala variant of the human PPAR gamma 2 gene on adiposity and insulin resistance, we studied the effect of the variant on fat distribution assessed by CT scan, plasma glucose, and insulin levels during a 75g oral glucose load in 215 non-diabetic Japanese men. The allele frequency of the variant was 0.03 in this population. There were no differences in body mass index (BMI), subcutaneous fat area (S), visceral fat area (V), V/S ratio, fasting plasma insulin levels, or insulin resistance index in homeostatic model assessment between 203 subjects who were homozygous for the wild-type Pro12 allele and 12 subjects with the variant Ala12 allele (11 heterozygotes and one homozygote). These data suggest that the Pro12Ala variant is not a major contributor to adiposity, fat distribution, or insulin resistance in Japanese men. (C) 1998 Academic Press.
引用
收藏
页码:195 / 198
页数:4
相关论文
共 22 条
[1]   Activators of peroxisome proliferator-activated receptor γ have depot-specific effects on human preadipocyte differentiation [J].
Adams, M ;
Montague, CT ;
Prins, JB ;
Holder, JC ;
Smith, SA ;
Sanders, L ;
Digby, JE ;
Sewter, CP ;
Lazar, MA ;
Chatterjee, VKK ;
O'Rahilly, S .
JOURNAL OF CLINICAL INVESTIGATION, 1997, 100 (12) :3149-3153
[2]  
[Anonymous], 1985, WHO TECH REP SER, V727, P7
[3]  
BEAMER BA, 1998, IN PRESS DIABETES
[4]  
DEEB SS, 1997, 9 INT CTR BIOT CBT S
[5]   Molecular cloning, expression and characterization of human peroxisome proliferator activated receptors gamma 1 and gamma 2 [J].
Elbrecht, A ;
Chen, YL ;
Cullinan, CA ;
Hayes, N ;
Leibowitz, MD ;
Moller, DE ;
Berger, J .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1996, 224 (02) :431-437
[6]   15-DEOXY-DELTA(12,14)-PROSTAGLANDIN J(2) IS A LIGAND FOR THE ADIPOCYTE DETERMINATION FACTOR PPAR-GAMMA [J].
FORMAN, BM ;
TONTONOZ, P ;
CHEN, J ;
BRUN, RP ;
SPIEGELMAN, BM ;
EVANS, RM .
CELL, 1995, 83 (05) :803-812
[7]   A prospective analysis of the HOMA model - The Mexico City Diabetes Study [J].
Haffner, SM ;
Gonzalez, C ;
Miettinen, H ;
Kennedy, E ;
Stern, MP .
DIABETES CARE, 1996, 19 (10) :1138-1141
[8]   A mutation of the beta 3-adrenergic receptor is associated with visceral obesity but decreased serum triglyceride [J].
KimMotoyama, H ;
Yasuda, K ;
Yamaguchi, T ;
Yamada, N ;
Katakura, T ;
Shuldiner, AR ;
Akanuma, Y ;
Ohashi, Y ;
Yazaki, Y ;
Kadowaki, T .
DIABETOLOGIA, 1997, 40 (04) :469-472
[9]   AN ANTIDIABETIC THIAZOLIDINEDIONE IS A HIGH-AFFINITY LIGAND FOR PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA(PPAR-GAMMA) [J].
LEHMANN, JM ;
MOORE, LB ;
SMITHOLIVER, TA ;
WILKISON, WO ;
WILLSON, TM ;
KLIEWER, SA .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (22) :12953-12956
[10]   HOMEOSTASIS MODEL ASSESSMENT - INSULIN RESISTANCE AND BETA-CELL FUNCTION FROM FASTING PLASMA-GLUCOSE AND INSULIN CONCENTRATIONS IN MAN [J].
MATTHEWS, DR ;
HOSKER, JP ;
RUDENSKI, AS ;
NAYLOR, BA ;
TREACHER, DF ;
TURNER, RC .
DIABETOLOGIA, 1985, 28 (07) :412-419