Activation of the HIF pathway in cancer

被引：333

作者：

Maxwell, PH

Pugh, CW

Ratcliffe, PJ

机构：

[1] The Henry Wellcome Building of Genomic Medicine, Oxford OX3 7BN, Roosevelt Drive

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2001年 / 11卷 / 03期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

D O I：

10.1016/S0959-437X(00)00193-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The maintenance of oxygen homeostasis is required both in physiological development and tumour growth. Hypoxia inducible factor (HIF) plays a central role in both processes. Reliable methods for visualising HIF a subunits have established that HIF activation occurs in the majority of common cancers. This occurs both by genetic mechanisms and through microenviromental hypoxia. Activation of the HIF pathway has important effects on patterns of gene expression in tumours.

引用

收藏

页码：293 / 299

页数：7

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