Practical method for the parallel synthesis of 2′-amido-2′-deoxyadenosines

被引：20

作者：

Link, A

van Calenbergh, S

Herdewijn, P

机构：

[1] Univ Hamburg, Inst Pharm, D-20146 Hamburg, Germany

[2] Univ Ghent, Fac Farm Wetenschappen, B-9000 Ghent, Belgium

[3] Katholieke Univ Leuven, Rega Inst, B-3000 Louvain, Belgium

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 29期

关键词：

amino sugars; combinatorial chemistry; nucleosides; supported reagents/reactions;

D O I：

10.1016/S0040-4039(98)01057-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new synthetic strategy for the simple and high yielding preparation of arrays of 2'-amido-2'-deoxyadenosine derivatives ready for biological testing without the need for chromatographic purification is described. Acids are coupled to the Kenner or Ellman safety catch linker, respectively, activated by cyanomethylation and subsequently transferred to the 2'-amino group of 2'-amino-2'-deoxyadenosine. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：5175 / 5176

页数：2

共 2 条

[1] Activation method to prepare a highly reactive acylsulfonamide ''safety-catch'' linker for solid-phase synthesis [J].