Occult hepatitis B virus infection in HIV-infected patients with isolated antibodies to hepatitis B core antigen:: Aquitaine cohort, 2002-2003

被引:57
作者
Neau, D
Winnock, M
Jouvencel, AC
Faure, M
Castéra, L
Legrand, E
Lacoste, D
Ragnaud, JM
Dupon, M
Fleury, H
Lafon, ME
Dabis, F
机构
[1] CHU Pellegrin, Federat Malad Infect & Trop, F-33076 Bordeaux, France
[2] INSERM, U593, Inst Epidemiol Sante Publ & Dev, F-75654 Paris 13, France
[3] CHU Victor Segalen, Virol Lab, Bordeaux, France
[4] CHU St Andre, Serv Hepato Gastroenterol, Bordeaux, France
[5] Hop Haut Leveque, Bordeaux, France
[6] CHU St Andre, Federat Med Interne & Malad Infect, Bordeaux, France
关键词
D O I
10.1086/427882
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
We prospectively assessed the prevalence of occult hepatitis B virus (HBV) infection by investigating HBV replication in 160 human immunodeficiency virus (HIV)-infected patients with isolated antibodies to hepatitis B core antigen. This prevalence was 0.6% (1 case/160 patients; 95% confidence interval, 0%-3.4%). A second serum sample was collected later from 52 of the patients. HBV DNA was once again undetectable in all patients, except for the sole patient who had previously been found to be HBV DNA positive.
引用
收藏
页码:750 / 753
页数:4
相关论文
共 24 条
[1]   Effects of lamivudine on replication of hepatitis B virus in HIV-infected men [J].
Benhamou, Y ;
Katlama, C ;
Lunel, F ;
Coutellier, A ;
Dohin, E ;
Hamm, N ;
Tubiana, R ;
Herson, S ;
Poynard, T ;
Opolon, P .
ANNALS OF INTERNAL MEDICINE, 1996, 125 (09) :705-+
[2]   Long-term incidence of hepatitis B virus resistance to lamivudine in human immunodeficiency virus-infected patients [J].
Benhamou, Y ;
Bochet, M ;
Thibault, V ;
Di Martino, V ;
Caumes, E ;
Bricaire, F ;
Opolon, P ;
Katlama, C ;
Poynard, T .
HEPATOLOGY, 1999, 30 (05) :1302-1306
[3]   Persistent hepatitis B virus infection in subjects without hepatitis B surface antigen:: Clinically significant or purely "occult"? [J].
Bréchot, C ;
Thiers, V ;
Kremsdorf, D ;
Nalpas, B ;
Pol, S ;
Paterlini-Bréchot, P .
HEPATOLOGY, 2001, 34 (01) :194-203
[4]   Occult hepatitis B virus infection: A hidden menace? [J].
Conjeevaram, H ;
Lok, AS .
HEPATOLOGY, 2001, 34 (01) :204-206
[5]   Clinical significance of hepatitis B core antibody positivity in HCV-infected and HCV/HIV coinfected individuals [J].
Cooper, C ;
Kilby, D .
CLINICAL INFECTIOUS DISEASES, 2004, 38 (09) :1335-1337
[6]   Isolated antibody to hepatitis B core antigen in human immunodeficiency virus type-1-infected individuals [J].
Gandhi, RT ;
Wurcel, A ;
Lee, H ;
McGovern, B ;
Boczanowski, M ;
Gerwin, R ;
Corcoran, CP ;
Szczepiorkowski, Z ;
Toner, S ;
Cohen, DE ;
Sax, PE ;
Ukomadu, C .
CLINICAL INFECTIOUS DISEASES, 2003, 36 (12) :1602-1605
[7]  
Grob P, 2000, J MED VIROL, V62, P450, DOI 10.1002/1096-9071(200012)62:4&lt
[8]  
450::AID-JMV9&gt
[9]  
3.0.CO
[10]  
2-Y