Methylphenidate enhances prepulse inhibition during processing of task-relevant stimuli in attention-deficit/hyperactivity disorder

被引：21

作者：

Ashare, Rebecca L.

Hawk, Larry W., Jr. ^{[1
]}

Shiels, Keri

Rhodes, Jessica D.

Pelham, William E., Jr. ^{[1
,2
]}

Waxmonsky, James G. ^{[3
]}

机构：

[1] SUNY Buffalo, Dept Psychol, Ctr Children & Families, Buffalo, NY 14260 USA

[2] SUNY Buffalo, Ctr Children & Families, Dept Pediat, Buffalo, NY 14260 USA

[3] SUNY Buffalo, Ctr Children & Families, Dept Psychiat, Buffalo, NY 14260 USA

来源：

PSYCHOPHYSIOLOGY | 2010年 / 47卷 / 05期

关键词：

Startle eyeblink; Cognition; Psychopharmacology; Psychopathology; DEFICIT HYPERACTIVITY DISORDER; CONTINUOUS PERFORMANCE-TEST; ACOUSTIC STARTLE-REFLEX; MOTIVATED ATTENTION; RESPONSE-INHIBITION; CHILDREN; ADHD; SCHIZOPHRENIA; RATS; BOYS;

D O I：

10.1111/j.1469-8986.2010.01001.x

中图分类号：

B84 [心理学];

学科分类号：

04 ; 0402 ;

摘要：

ADHD is characterized by inattention, hyperactivity, and disinhibition, including the inability to screen out distracting stimuli. Prepulse inhibition (PPI) of startle indexes a related gating process and is enhanced during attended compared to ignored stimuli. We predicted that PPI during attended stimuli would be enhanced by the stimulant methylphenidate (MPH) and that this effect would be moderated by baseline PPI. Children with ADHD (n=36) completed a baseline day and a randomized, double-blind medication trial (placebo vs. sustained release MPH). Bilateral startle eyeblink EMG was measured during a tone discrimination task. MPH enhanced PPI during attended, but not during ignored stimuli. Extending findings that pretreatment functioning moderates stimulant effects on PPI, this effect tended to be inversely related to baseline PPI. These data fit with the clinical literature on ADHD and the hypothesis that MPH enhances interference control for important environmental stimuli.

引用

页码：838 / 845

页数：8

共 63 条

[1]

[Anonymous], 2000, DIAGN STAT MAN MENT, DOI DOI 10.1176/APPI.BOOKS.9780890425787

[2] Sex differences in ADHD: Conference summary [J].

Arnold, LE .

JOURNAL OF ABNORMAL CHILD PSYCHOLOGY, 1996, 24 (05) :555-569

[3] Motivated attention: Incentive effects on attentional modification of prepulse inhibition [J].

Ashare, Rebecca L. ;

Hawk, Larry W., Jr. ;

Mazzullo, Rebecca J. .

PSYCHOPHYSIOLOGY, 2007, 44 (06) :839-845

[4]

BAKSHI VP, 1994, J PHARMACOL EXP THER, V271, P787

[5]

Barkley R.A., 2007, ADHD in adults: What the science says

[6] Behavioral inhibition, sustained attention, and executive functions: Constructing a unifying theory of ADHD [J].

Barkley, RA .

PSYCHOLOGICAL BULLETIN, 1997, 121 (01) :65-94

[7] The effects of nicotine on the attentional modification of the acoustic startle response in nonsmokers [J].

Baschnagel, Joseph S. ;

Hawk, Larry W., Jr. .

PSYCHOPHARMACOLOGY, 2008, 198 (01) :93-101

[8] Motivated attention and prepulse inhibition of startle in rats: Using conditioned reinforcers as prepulses [J].

Baschnagel, Joseph S. ;

Hawk, Larry W., Jr. ;

Colder, Craig R. ;

Richards, Jerry B. .

BEHAVIORAL NEUROSCIENCE, 2007, 121 (06) :1372-1382

[9] The effects of dopamine agonists on prepulse inhibition in healthy men depend on baseline PPI values [J].

Bitsios, P ;

Giakoumaki, SG ;

Frangou, S .

PSYCHOPHARMACOLOGY, 2005, 182 (01) :144-152

[10] Relationship of prepulse inhibition of the startle reflex to attentional and executive mechanisms in man [J].

Bitsios, P ;

Giakoumaki, SG .

INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY, 2005, 55 (02) :229-241

← 1 2 3 4 5 6 7 →