Estrogen-related receptors in breast cancer and prostate cancer

被引：61

作者：

Misawa, Aya ^{[1
]}

Inoue, Satoshi ^{[1
,2
]}

机构：

[1] Univ Tokyo, Grad Sch Med, Dept Antiaging Med, 7-3-1 Hongo, Tokyo 1138655, Japan

[2] Saitama Med Univ, Res Ctr Genom Med, Div Gene Regulat & Signal Transduct, Saitama, Japan

来源：

FRONTIERS IN ENDOCRINOLOGY | 2015年 / 6卷

关键词：

estrogen-related receptors; estrogen receptors; estrogen; androgen; breast cancer; prostate cancer; ORPHAN NUCLEAR RECEPTORS; ALPHA ERR-ALPHA; THERAPEUTIC TARGET; TRANSCRIPTIONAL REGULATION; SULFOTRANSFERASE SULT2A1; DIFFERENTIAL EXPRESSION; MOLECULAR PORTRAITS; ANDROGEN RECEPTOR; GENE-EXPRESSION; NEGATIVE TUMORS;

D O I：

10.3389/fendo.2015.00083

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Estrogen-signaling pathways are implicated in the development of breast cancer and prostate cancer. Various studies have focused on additional signaling pathways, mediated by estrogen-related receptors (ERRs). ERRs are constitutively active receptors that share a high degree of homology with the classical estrogen receptors (ERs). However, they do not bind to estrogen, while ERs do. ERRs are involved in the development of alternative pathways that lead to the development of cancer and are regarded as potential therapeutic targets for the treatment of breast cancer and prostate cancer that do not respond to conventional therapies. In this review, we first present general structural features of ERRs. Then, we focus on breast cancer and prostate cancer, which are primarily hormone-dependent cancers, and summarizes recent progress in elucidating the involvement of each ERR in these two types of malignancies.

引用

页数：7

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