Induction of hippocampal glial cells expressing basic fibroblast growth factor RNA by corticosterone

被引：3

作者：

Hansson, AC ^{[1
]}

Sommer, W

Andbjer, B

Bader, M

Ganten, D

Fuxe, K

机构：

[1] Karolinska Inst, Dept Neurosci, Div Mol & Cellular Neurochem, S-17177 Stockholm, Sweden

[2] Karolinska Inst, NEUROTEC, S-17177 Stockholm, Sweden

[3] Max Delbruck Ctr Mol Med, D-13125 Berlin, Germany

来源：

NEUROREPORT | 2001年 / 12卷 / 01期

关键词：

ADX; bFGF; corticosterone; gene regulation; in situ hybridization; rat brain;

D O I：

10.1097/00001756-200101220-00036

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A transcriptional regulation of bFGF expression via both gluco- and mineralocorticoid receptors is known to exist. In the present study the glial nuclear fraction of bFGF transcripts was studied in sham-operated (SHAM), adrenalectomized (ADX), and corticosterone-treated ADX rats in subregions of the dorsal hippocampal formation. A substantial increase was observed in the population of bFGF RNA-expressing glial cells after acute corticosterone treatment (10 mg/kg, s.c.) in subregions of the CA1 area and the dentate gyrus but no changes were observed after adrenalectomy. The levels of glial nuclear bFGF transcripts were similar in all the experimental groups. These data suggest that in a subpopulation of hippocampal glial cells corticosterone regulates bFGF gene expression transcriptionally in an on/off manner. NeuroReport 12:141-145 (C) 2001 Lippincott Williams & Wilkins.

引用

页码：141 / 145

页数：5

共 21 条

[1] PHORBOL ESTER INDUCIBLE GENES CONTAIN A COMMON CIS ELEMENT RECOGNIZED BY A TPA-MODULATED TRANS-ACTING FACTOR [J].

ANGEL, P ;

IMAGAWA, M ;

CHIU, R ;

STEIN, B ;

IMBRA, RJ ;

RAHMSDORF, HJ ;

JONAT, C ;

HERRLICH, P ;

KARIN, M .

CELL, 1987, 49 (06) :729-739

[2] CHANGES IN RAT PITUITARY NUCLEAR AND CYTOPLASMIC PRO-OPIOMELANOCORTIN RNAS ASSOCIATED WITH ADRENALECTOMY AND GLUCOCORTICOID REPLACEMENT [J].

AUTELITANO, DJ ;

BLUM, M ;

ROBERTS, JL .

MOLECULAR AND CELLULAR ENDOCRINOLOGY, 1989, 66 (02) :171-180

[3] PRODUCTION OF LABELED CRNA PROBES WITHOUT VECTOR CLONING - APPLICATION TO LOCALIZATION OF BASIC FIBROBLAST GROWTH-FACTOR AND TYROSINE-HYDROXYLASE MESSENGER-RNAS BY INSITU HYBRIDIZATION HISTOCHEMISTRY [J].

BEAN, AJ ;

SIMONS, JF ;

HOKFELT, T .

MOLECULAR AND CELLULAR NEUROSCIENCE, 1993, 4 (02) :216-221

[4] CORTICOSTERONE INCREASES FGF-2 (BFGF) IMMUNOREACTIVITY IN THE SUBSTANTIA-NIGRA OF THE RAT [J].

CHADI, G ;

ROSEN, L ;

CINTRA, A ;

TINNER, B ;

ZOLI, M ;

PETTERSSON, RF ;

FUXE, K .

NEUROREPORT, 1993, 4 (06) :783-786

[5] Adrenal steroid regulation of neurotrophic factor expression in the rat hippocampus [J].

Chao, HM ;

Sakai, RR ;

Ma, LY ;

McEwen, BS .

ENDOCRINOLOGY, 1998, 139 (07) :3112-3118

[6] GLUCOCORTICOIDS AND THE EXPRESSION OF MESSENGER-RNAS FOR NEUROTROPHINS, THEIR RECEPTORS AND GAP-43 IN THE RAT HIPPOCAMPUS [J].

CHAO, HM ;

MCEWEN, BS .

MOLECULAR BRAIN RESEARCH, 1994, 26 (1-2) :271-276

[7] A NUCLEAR POSTTRANSCRIPTIONAL MECHANISM MEDIATES THE INDUCTION OF FIBRONECTIN BY GLUCOCORTICOIDS [J].

EHRETSMANN, CP ;

CHANDLER, LA ;

BOURGEOIS, S .

MOLECULAR AND CELLULAR ENDOCRINOLOGY, 1995, 110 (1-2) :185-194

[8] BIOCHEMISTRY, MOLECULAR-BIOLOGY, AND PHYSIOLOGY OF THE GLUCOCORTICOID RECEPTOR [J].

GUSTAFSSON, JA ;

CARLSTEDTDUKE, J ;

POELLINGER, L ;

OKRET, S ;

WIKSTROM, AC ;

BRONNEGARD, M ;

GILLNER, M ;

YU, D ;

FUXE, K ;

CINTRA, A ;

HARFSTRAND, A ;

AGNATI, L .

ENDOCRINE REVIEWS, 1987, 8 (02) :185-234

[9]

Hansson A. C., 1997, Society for Neuroscience Abstracts, V23, P48

[10] Gluco- and mineralocorticoid receptor-mediated regulation of neurotrophic factor gene expression in the dorsal hippocampus and the neocortex of the rat [J].

Hansson, AC ;

Cintra, A ;

Belluardo, N ;

Sommer, W ;

Bhatnagar, M ;

Bader, M ;

Ganten, D ;

Fuxe, K .

EUROPEAN JOURNAL OF NEUROSCIENCE, 2000, 12 (08) :2918-2934

← 1 2 3 →