Activation of tetrabutylammonium hydrogen difluoride with pyridine: A mild and efficient procedure for nucleophilic fluorination

被引：30

作者：

Moughamir, K

Atmani, A

Mestdagh, H

Rolando, C

Francesch, C

机构：

[1] Ecole Normale Super, Dept Chim, CNRS, F-75231 Paris 05, France

[2] Univ Sidi Mohamed Ben Abdellah, Fac Sci, Chim Organ Lab, Fes 30000, Morocco

[3] IUFM Paris, F-75016 Paris, France

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 40期

关键词：

D O I：

10.1016/S0040-4039(98)01564-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The nucleophilic fluorination of alkyl iodides, bromides and tosylates and of alpha-bromo- or alpha-chloroketones is smoothly effected by tetrabutylammonium hydrogen difluoride in the presence of pyridine, in dioxane or THF, with good or satisfying substitution-to-elimination ratio. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.

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页码：7305 / 7306

页数：2

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