Prepregnancy cardiovascular risk factors as predictors of pre-eclampsia:: population based cohort study

被引:274
作者
Magnussen, Elisabeth Balstad [1 ]
Vatten, Lars Johan
Lund-Nilsen, Tom Ivar
Salvesen, Kjell Asmund
Smith, George Davey
Romundstad, Pal Richard
机构
[1] Norwegian Univ Sci & Technol, Fac Med, Dept Publ Hlth, N-7489 Trondheim, Norway
[2] Trondheim Univ Hosp St Olav, Dept Obstet, Trondheim, Norway
[3] Univ Bristol, Dept Social Med, Bristol BS8 1TH, Avon, England
来源
BRITISH MEDICAL JOURNAL | 2007年 / 335卷 / 7627期
关键词
D O I
10.1136/bmj.39366.416817.BE
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective To examine the effect of cardiovascular risk factors before pregnancy on risk of pre-eclampsia. Design Population based prospective study. Setting Linkage between a Norwegian population based study (Nord-Trondelag health study, HUNT-2) and Norway's medical birth registry. Participants 3494 women who gave birth after participating in the Nord-Trondelag health study at baseline; of whom 133 (3.81%) delivered after a preeclamptic pregnancy. Main outcome measure Odds ratio of developing preeclampsia. Results After adjustment for smoking; previous preeclampsia; parity; maternal age, education, and socioeconomic position; and duration between baseline measurements and delivery, positive associations were found between prepregnancy serum levels of trigtycerides, cholesterol, low density lipoprotein cholesterol, non-high density lipoprotein cholesterol, and blood pressure and risk of pre-eclampsia. The odds ratio of developing preectampsia for women with baseline systolic blood pressures greater than 130 mm fig (highest fifth) was 7.3 (95% confidence interval 3.1 to 17.2) compared with women with systolic blood pressures less than 111 mm Hg (lowest fifth). Similar results were found for nulliparous and parous women. Women who used oral contraceptives at baseline had half the risk of pre-eclampsia compared with never or former users (0.5, 0.3 to 0.9). Conclusion Women with cardiovascular risk factors may be predisposed to pre-eclampsia.
引用
收藏
页码:978 / 981
页数:6
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