Synthesis of cyclic and acyclic β-amino acids via chelation-controlled 1,3-dipolar cycloaddition

被引：57

作者：

Hanselmann, R ^{[1
]}

Zhou, JC ^{[1
]}

Ma, P ^{[1
]}

Confalone, PN ^{[1
]}

机构：

[1] Bristol Myers Squibb Co, Expt Stn, Wilmington, DE 19880 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2003年 / 68卷 / 22期

关键词：

D O I：

10.1021/jo034940o

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Isoxazolidines have been synthesized in diastereomeric excess up to 94% via a MgBr2-induced chelation-controlled 1,3-dipolar cycloaddition reaction with N-hydroxyphenylglycinol as a chiral auxiliary. The diastereomerically pure isoxazolidines were further transformed into cyclic and acyclic beta-amino acid derivatives.

引用

页码：8739 / 8741

页数：3

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