Genetic disorders of membrane transport I. Glucose galactose malabsorption

被引：104

作者：

Wright, EM ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Sch Med, Dept Physiol, Los Angeles, CA 90095 USA

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY | 1998年 / 275卷 / 05期

关键词：

sodium-glucose cotransporter; genetic disease; protein trafficking;

D O I：

10.1152/ajpgi.1998.275.5.G879

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Glucose Galactose Malabsorption is a genetic disorder caused by a defect in glucose and galactose transport across the intestinal brush border. Normally, lactose in milk is broken down into glucose and galactose by lactase, an ectoenzyme on the brush border, and the hexoses are transported into the cell by the Na+-glucose cotransporter SGLT1. The mutations causing the defect in sugar transport have been identified in patients from 33 kindreds, and functional studies have established how these mutations cause the disease.

引用

页码：G879 / G882

页数：4

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