Background: Surgery for morbid obesity is rapidly increasing. Patients undergoing bariatric surgery are prone to gallstone development during the rapid weight loss. These patients are often given medications such as ursodeoxycholic acid to prevent gallstone formation; however, these medications are often poorly tolerated by patients, who subsequently discontinue them. We performed a study in a lithogenic animal model to assess the effectiveness of a potential alternate medication for gallstone prevention. Methods: 20 male prairie dogs were randomly separated into 2 groups and fed a lithogenic diet for 28 days. The study group animals were given 2.5 mg of the HMG-CoA reductase inhibitor simvastatin. Total cholesterol and triglycerides were measured and an open cholecystectomy was performed on each animal at the conclusion of the study period. The gallbladder was visually inspected for gallstones and microscopic biliary cholesterol crystal formation. Results: There was a decrease of 36% in the total cholesterol of the study animals compared to controls. The animals treated with simvastatin showed gallstone formation in 5/10 (50%) of animals, compared with 6/10 (60%) of control animals. The study animals demonstrated microscopic cholesterol crystal formation in 80%, identical to the number found in the control animals. Conclusion: Despite a reduction in cholesterol, simvastatin prevented neither gallstone formation nor biliary cholesterol crystals in this animal model. Given the rapid increase in the number of bariatric surgical procedures coupled with the poor tolerance of ursodeoxycholic acid, viable alternatives should continue to be sought for these patients.
机构:
Univ Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USAUniv Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USA
Mason, EE
;
Renquist, KE
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机构:
Univ Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USAUniv Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USA
Renquist, KE
;
Angus, LDG
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h-index: 0
机构:
Univ Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USAUniv Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USA
Angus, LDG
;
Baker, DJ
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USAUniv Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USA
Baker, DJ
;
Baker, JW
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USAUniv Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USA
Baker, JW
;
Betcher, RA
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USAUniv Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USA
Betcher, RA
;
Cleator, AGM
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USAUniv Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USA
Cleator, AGM
;
Clough, DM
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USAUniv Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USA
Clough, DM
;
Cox, S
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USAUniv Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USA
Cox, S
;
Doherty, C
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USAUniv Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USA
Doherty, C
;
Drew, R
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USAUniv Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USA
Drew, R
;
Ediger, AJ
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h-index: 0
机构:
Univ Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USAUniv Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USA
Ediger, AJ
;
Fobi, MAL
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USAUniv Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USA
Fobi, MAL
;
Gleysteen, JJ
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h-index: 0
机构:
Univ Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USAUniv Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USA
Gleysteen, JJ
;
Halverson, JD
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USAUniv Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USA
Halverson, JD
;
Jaroch, MT
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USAUniv Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USA
Jaroch, MT
;
Jones, KB
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USAUniv Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USA
Jones, KB
;
Lee, H
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USAUniv Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USA
Lee, H
;
LePort, P
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USAUniv Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USA
LePort, P
;
Lirio, OC
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USAUniv Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USA
Lirio, OC
;
MacPherson, BH
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USAUniv Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USA
MacPherson, BH
;
Maher, JW
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USAUniv Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USA
Maher, JW
;
Marema, RI
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USAUniv Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USA
Marema, RI
;
Mason, EE
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USAUniv Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USA
Mason, EE
;
Murphy, LJ
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USAUniv Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USA
Murphy, LJ
;
Popoola, D
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USAUniv Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USA
Popoola, D
;
Rumsey, EW
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USAUniv Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USA
Rumsey, EW
;
Rupp, W
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USAUniv Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USA
Rupp, W
;
Schechner, SA
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USAUniv Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USA
Schechner, SA
;
Schwartz, M
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USAUniv Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USA
Schwartz, M
;
Scott, TC
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USAUniv Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USA
Scott, TC
;
Stoner, JA
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USAUniv Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USA
Stoner, JA
;
Tanaka, LK
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h-index: 0
机构:
Univ Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USAUniv Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USA
Tanaka, LK
;
Zorn, GG
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USAUniv Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USA
机构:
Univ Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USAUniv Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USA
Mason, EE
;
Renquist, KE
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USAUniv Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USA
Renquist, KE
;
Angus, LDG
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USAUniv Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USA
Angus, LDG
;
Baker, DJ
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USAUniv Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USA
Baker, DJ
;
Baker, JW
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USAUniv Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USA
Baker, JW
;
Betcher, RA
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USAUniv Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USA
Betcher, RA
;
Cleator, AGM
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USAUniv Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USA
Cleator, AGM
;
Clough, DM
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USAUniv Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USA
Clough, DM
;
Cox, S
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USAUniv Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USA
Cox, S
;
Doherty, C
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USAUniv Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USA
Doherty, C
;
Drew, R
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USAUniv Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USA
Drew, R
;
Ediger, AJ
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USAUniv Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USA
Ediger, AJ
;
Fobi, MAL
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USAUniv Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USA
Fobi, MAL
;
Gleysteen, JJ
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USAUniv Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USA
Gleysteen, JJ
;
Halverson, JD
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USAUniv Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USA
Halverson, JD
;
Jaroch, MT
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USAUniv Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USA
Jaroch, MT
;
Jones, KB
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USAUniv Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USA
Jones, KB
;
Lee, H
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USAUniv Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USA
Lee, H
;
LePort, P
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USAUniv Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USA
LePort, P
;
Lirio, OC
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USAUniv Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USA
Lirio, OC
;
MacPherson, BH
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USAUniv Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USA
MacPherson, BH
;
Maher, JW
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USAUniv Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USA
Maher, JW
;
Marema, RI
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USAUniv Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USA
Marema, RI
;
Mason, EE
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USAUniv Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USA
Mason, EE
;
Murphy, LJ
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USAUniv Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USA
Murphy, LJ
;
Popoola, D
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USAUniv Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USA
Popoola, D
;
Rumsey, EW
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USAUniv Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USA
Rumsey, EW
;
Rupp, W
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USAUniv Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USA
Rupp, W
;
Schechner, SA
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USAUniv Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USA
Schechner, SA
;
Schwartz, M
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USAUniv Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USA
Schwartz, M
;
Scott, TC
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USAUniv Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USA
Scott, TC
;
Stoner, JA
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USAUniv Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USA
Stoner, JA
;
Tanaka, LK
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USAUniv Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USA
Tanaka, LK
;
Zorn, GG
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USAUniv Iowa, Coll Med, Dept Surg, Int Bariatr Surg Registry, Iowa City, IA 52242 USA