The RNA-Methyltransferase Misu (NSun2) Poises Epidermal Stem Cells to Differentiate

被引：163

作者：

Blanco, Sandra ^{[1
]}

Kurowski, Agata ^{[1
]}

Nichols, Jennifer ^{[1
]}

Watt, Fiona M. ^{[1
,2
]}

Aznar Benitah, Salvador ^{[3
,4
]}

Frye, Michaela ^{[1
]}

机构：

[1] Univ Cambridge, Wellcome Trust Ctr Stem Cell Res, Cambridge, England

[2] Li Ka Shing Ctr, CR UK Cambridge Res Inst, Cambridge, England

[3] Inst Catalana Recerca & Estudis Avancats ICREA, Ctr Genom Res CRG, Barcelona, Spain

[4] Inst Catalana Recerca & Estudis Avancats ICREA, UPF, Barcelona, Spain

来源：

PLOS GENETICS | 2011年 / 7卷 / 12期

基金：

英国医学研究理事会;

关键词：

HAIR FOLLICLE MORPHOGENESIS; BETA-CATENIN; SACCHAROMYCES-CEREVISIAE; TRANSIENT ACTIVATION; LINEAGE COMMITMENT; MOUSE EPIDERMIS; MYC ACTIVATION; SELF-RENEWAL; PROLIFERATION; METHYLATION;

D O I：

10.1371/journal.pgen.1002403

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Homeostasis of most adult tissues is maintained by balancing stem cell self-renewal and differentiation, but whether post-transcriptional mechanisms can regulate this process is unknown. Here, we identify that an RNA methyltransferase (Misu/Nsun2) is required to balance stem cell self-renewal and differentiation in skin. In the epidermis, this methyltransferase is found in a defined sub-population of hair follicle stem cells poised to undergo lineage commitment, and its depletion results in enhanced quiescence and aberrant stem cell differentiation. Our results reveal that post-transcriptional RNA methylation can play a previously unappreciated role in controlling stem cell fate.

引用

页数：14

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