Selective Killing of Bacterial Persisters by a Single Chemical Compound without Affecting Normal Antibiotic-Sensitive Cells

被引：84

作者：

Kim, Jun-Seob ^{[1
,2
]}

Heo, Paul ^{[1
,2
]}

Yang, Tae-Jun ^{[1
,2
]}

Lee, Ki-Sing ^{[1
,2
]}

Cho, Da-Hyeong ^{[1
,2
]}

Kim, Bum Tae ^{[3
]}

Suh, Ji-Hee ^{[3
]}

Lim, Hee-Jong ^{[3
]}

Shin, Dongwoo ^{[4
]}

Kim, Sung-Koo ^{[5
]}

Kweon, Dae-Hyuk ^{[1
,2
]}

机构：

[1] Sungkyunkwan Univ, Sch Life Sci & Biotechnol, Suwon 440746, Gyeonggi Do, South Korea

[2] Sungkyunkwan Univ, Ctr Human Interface Nano Technol, Suwon 440746, Gyeonggi Do, South Korea

[3] Korea Res Inst Chem Technol, Taejon 305600, South Korea

[4] Sungkyunkwan Univ, Sch Med, Suwon 440746, Gyeonggi Do, South Korea

[5] Pukyong Natl Univ, Dept Biotechnol & Bioengn, Pusan 608737, South Korea

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2011年 / 55卷 / 11期

基金：

新加坡国家研究基金会;

关键词：

MULTIDRUG TOLERANCE; ESCHERICHIA-COLI; RESISTANCE; BIOFILMS; SWITCH;

D O I：

10.1128/AAC.00708-11

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We show that 3-[4-(4-methoxyphenyl)piperazin-1-yl]piperidin-4-yl biphenyl-4-carboxylate (C10), screened out of a chemical library, selectively kills bacterial persisters that tolerate antibiotic treatment but does not affect normal antibiotic-sensitive cells. C10 led persisters to antibiotic-induced cell death by causing reversion of persisters to antibiotic-sensitive cells. This work is the first demonstration in which the eradication of bacterial persisters is based on single-chemical supplementation. The chemical should be versatile in elucidating the mechanism of persistence.

引用

页码：5380 / 5383

页数：4

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