Targeting osteoclast-osteoblast communication

被引：139

作者：

Cao, Xu ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Orthopaed Surg, Baltimore, MD 21218 USA

来源：

NATURE MEDICINE | 2011年 / 17卷 / 11期

关键词：

BONE-RESORPTION; RECEPTOR; CELLS;

D O I：

10.1038/nm.2499

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The identification of a new mode of cell-cell communication mediated by semaphorin 4D (Sema4D) and Plexin-B1 has added another level to the regulatory balance between bone formation and resorption (pages 1473-1480). This study also highlights Sema4D as a potential target for the development of new therapeutics for osteoporosis and other bone disorders associated with increased resorption.

引用

页码：1344 / 1346

页数：4

共 12 条

[1]

An estimate of the worldwide prevalence and disability associated with osteoporotic fractures [J].

Johnell, O. ;

Kanis, J. A. .

OSTEOPOROSIS INTERNATIONAL, 2006, 17 (12) :1726-1733

[2]

Identification of CD72 as a lymphocyte receptor for the class IV semaphorin CD100: A novel mechanism for regulating B cell signaling [J].

Kumanogoh, A ;

Watanabe, C ;

Lee, I ;

Wang, XS ;

Shi, W ;

Araki, H ;

Hirata, H ;

Iwahori, K ;

Uchida, J ;

Yasui, T ;

Matsumoto, M ;

Yoshida, K ;

Yakura, H ;

Pan, C ;

Parnes, JR ;

Kikutani, H .

IMMUNITY, 2000, 13 (05) :621-631

[3]

Smad3 Regulates Rho Signaling via NET1 in the Transforming Growth Factor-β-induced Epithelial-Mesenchymal Transition of Human Retinal Pigment Epithelial Cells [J].

Lee, Jungeun ;

Moon, Hyun-Jeong ;

Lee, Jong-Min ;

Joo, Choun-Ki .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (34) :26618-26627

[4]

MATTHEW T, 2008, MAYO CLIN P, V83, P1032

[5]

Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment [J].

McBeath, R ;

Pirone, DM ;

Nelson, CM ;

Bhadriraju, K ;

Chen, CS .

DEVELOPMENTAL CELL, 2004, 6 (04) :483-495

[6]

Suppression of bone formation by osteoclastic expression of semaphorin 4D [J].

Negishi-Koga, Takako ;

Shinohara, Masahiro ;

Komatsu, Noriko ;

Bito, Haruhiko ;

Kodama, Tatsuhiko ;

Friedel, Roland H. ;

Takayanagi, Hiroshi .

NATURE MEDICINE, 2011, 17 (11) :1473-U181

[7]

Osteonecrosis of the jaw - Who gets it, and why? [J].

Reid, Ian R. .

BONE, 2009, 44 (01) :4-10

[8]

Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families [J].

Suda, T ;

Takahashi, N ;

Udagawa, N ;

Jimi, E ;

Gillespie, MT ;

Martin, TJ .

ENDOCRINE REVIEWS, 1999, 20 (03) :345-357

[9]

TGF-β1-induced migration of bone mesenchymal stem cells couples bone resorption with formation [J].

Tang, Yi ;

Wu, Xiangwei ;

Lei, Weiqi ;

Pang, Lijuan ;

Wan, Chao ;

Shi, Zhenqi ;

Zhao, Ling ;

Nagy, Timothy R. ;

Peng, Xinyu ;

Hu, Junbo ;

Feng, Xu ;

Van Hul, Wim ;

Wan, Mei ;

Cao, Xu .

NATURE MEDICINE, 2009, 15 (07) :757-U9

[10]

Bone resorption by osteoclasts [J].

Teitelbaum, SL .

SCIENCE, 2000, 289 (5484) :1504-1508

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