Propofol-related infusion syndrome induced by "moderate dosage" in a patient with severe head trauma

被引：11

作者：

Annecke, Thorsten ^{[1
]}

Conzen, Peter ^{[1
]}

Ney, Ludwig ^{[1
]}

机构：

[1] Univ Munich, Dept Anesthesiol, D-80336 Munich, Germany

来源：

JOURNAL OF CLINICAL ANESTHESIA | 2012年 / 24卷 / 01期

关键词：

Cardiac failure; Propofol-related infusion syndrome; Traumatic head injury; PATHOPHYSIOLOGY; SEDATION; UPDATE;

D O I：

10.1016/j.jclinane.2011.03.008

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Propofol is widely used for sedating critically ill adult patients because of its rapid onset and short recovery times, even after prolonged use. Propofol may be associated with a life-threatening syndrome, propofol-related infusion syndrome (PRIS), which includes cardiac failure, severe metabolic acidosis, renal failure, and rhabodomyolysis. The pathophysiology is incompletely understood. Propofol-related "infusion syndrome seems to be dose-related, and it occurs generally in patients undergoing long-term (> 48 hrs) sedation at higher doses (> 4 mg/kg/hr). A case of PRIS in a patient after severe head injury is presented. (C) 2012 Elsevier Inc. All rights reserved.

引用

页码：51 / 54

页数：4

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