Nonparametric trend test for the cumulative tumor incidence rate

被引：3

作者：

Kodell, RL ^{[1
]}

Ahn, H ^{[1
]}

机构：

[1] NATL CTR TOXICOL RES,BIOMETRY BRANCH,JEFFERSON,AR 72079

来源：

COMMUNICATIONS IN STATISTICS-THEORY AND METHODS | 1996年 / 25卷 / 08期

关键词：

bioassay; constrained maximization; delta method; expected information; interval sacrifice; power; size;

D O I：

10.1080/1532415X.1996.11877447

中图分类号：

O21 [概率论与数理统计]; C8 [统计学];

学科分类号：

020208 ; 070103 ; 0714 ;

摘要：

The fundamental approach of Malani and Van Ryzin (JASA, 1988) is utilized to develop a nonparametric test for dose-related trend for use with tumorigenicity data from animal bioassays that include interim sacrifices. By constraining the age-specific tumor incidence rate to be nonnegative, the proposed procedure improves both the size and power of the Malani-Van Ryzin test. A real-data example and a small Monte Carlo simulation study illustrate the improvements achieved by the new test.

引用

页码：1677 / 1692

页数：16

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