Stereoselective synthesis of (5S,6S)- and (5S,6R)-aza-muricatacin from an L-glutamic acid derivative

被引：24

作者：

Andrés, JM ^{[1
]}

de Elena, N ^{[1
]}

Pedrosa, R ^{[1
]}

Pérez-Encabo, A ^{[1
]}

机构：

[1] Univ Valladolid, Fac Ciencias, Dept Quim Organ, Valladolid 47011, Spain

来源：

TETRAHEDRON-ASYMMETRY | 2001年 / 12卷 / 10期

关键词：

D O I：

10.1016/S0957-4166(01)00251-8

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A stereodivergent synthesis of threo and erythro aza-muricatacin. a non-natural aza-analogue of the bioactive annonaceous acetogenin muricatacin, is presented. The configuration of the C(5) stereocenter is controlled by diastereoselective alkylation of alpha -dibenzylamino aldehyde I or diastercoselective reduction of alpha -dibenzylamino ketone 3. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：1503 / 1509

页数：7

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