Human embryonic stem cell lines derived from the Chinese population

被引：13

作者：

Fang, ZF

Jin, F

Gai, H

Chen, Y

Wu, L

Liu, AL

Chen, B

Sheng, HZ

机构：

[1] Shanghai Med Univ 2, Xinhua Hosp, Ctr Dev Biol, Shanghai 200092, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Biol Sci, Lab Stem Cell Biol, Inst Biochem & Cell Biol, Shanghai 200031, Peoples R China

[3] Zhejiang Univ, Sch Med, Fertilizat Ctr Womens Hosp, Zhejiang 310006, Peoples R China

来源：

CELL RESEARCH | 2005年 / 15卷 / 05期

关键词：

human embryonic stem cell; pluoripotent; cell line; teratoma;

D O I：

10.1038/sj.cr.7290307

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Six human embryonic stem cell lines were established from surplus blastocysts. The cell lines expressed alkaline phosphatase and molecules typical of primate embryonic stem cells, including Oct-4, Nanog, TDGF1, Sox2, EBAF, Thy-1, FGF4, Rex-1, SSEA-3, SSEA-4, TRA-1-60 and TRA-1-81. Five of the six lines formed embryoid bodies that expressed markers of a variety of cell types; four of them formed teratomas with tissue types representative of all three embryonic germ layers. These human embryonic stem cells are capable of producing clones of undifferentiated morphology, and one of them was propagated to become a subline. Human embryonic stem cell lines from the Chinese population should facilitate stem cell research and may be valuable in studies of population genetics and ecology.

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收藏

页码：394 / 400

页数：7

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