Toll-like receptors in inflammation of the central nervous system

被引：138

作者：

Kong, Yan ^{[1
]}

Le, Yingying ^{[2
]}

机构：

[1] Southeast Univ, Sch Med, Dept Biochem & Mol Biol, Nanjing 210009, Peoples R China

[2] Chinese Acad Sci, SIBS, Inst Nutr Sci, Lab Nutr & Inflammat Related Dis, Shanghai 200031, Peoples R China

来源：

INTERNATIONAL IMMUNOPHARMACOLOGY | 2011年 / 11卷 / 10期

基金：

中国国家自然科学基金;

关键词：

Toll-like receptors; Central nervous system; Inflammation; Infection; Injury; Autoimmune diseases; FOCAL CEREBRAL-ISCHEMIA; HERPES-SIMPLEX-VIRUS; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; EXPERIMENTAL SUBARACHNOID HEMORRHAGE; INNATE IMMUNITY; STAPHYLOCOCCUS-AUREUS; MULTIPLE-SCLEROSIS; BRAIN-INJURY; LETHAL ENCEPHALITIS; MYCOBACTERIUM-TUBERCULOSIS;

D O I：

10.1016/j.intimp.2011.04.025

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Toll-like receptors (TLRs) belong to pattern-recognition receptor family that could recognize exogenous pathogen-associated molecular patterns and endogenous damage-associated molecular patterns. TLRs play pivotal roles in innate and adaptive immune responses. In this review we summarize the ligands and signal transduction pathways of TLRs and highlight recent progress of the involvement of TLRs in neuroinflammation related disorders, including cerebral ischemia/stroke, brain trauma and hemorrhage, pathogen infection and autoimmune diseases, and explore the potential of TLR signaling as therapeutic targets against these disorders. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：1407 / 1414

页数：8

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