Kinetic study of the reaction of ebselen with peroxynitrite

被引：155

作者：

Masumoto, K

Kissner, R

Koppenol, WH

Sies, H

机构：

[1] UNIV DUSSELDORF,INST PHYSIOL CHEM 1,D-40001 DUSSELDORF,GERMANY

[2] ETH ZURICH,ANORGAN CHEM LAB,CH-8092 ZURICH,SWITZERLAND

来源：

FEBS LETTERS | 1996年 / 398卷 / 2-3期

关键词：

peroxynitrite; ebselen; rate constant; selenoorganic compound;

D O I：

10.1016/S0014-5793(96)01237-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The second-order rate constant for the reaction of ebselen with peroxynitrite (ONOO-) is (2.0+/-0.1) x 10(6) M(-1) s(-1) at pH greater than or equal to 8 and 25 degrees C, 3-4 orders of magnitude higher than the rate constants observed for cysteine, ascorbate, or methionine, The activation energy is relatively low, 12.8 kJ/mol, This is the fastest reaction of peroxynitrite observed so far, It may allow Se-containing compounds to play a novel role in the defense against peroxynitrite, one of the important reactive species generated during inflammatory processes.

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页码：179 / 182

页数：4

相关论文

共 27 条

[1] REACTION BETWEEN PEROXYNITRITE AND HYDROGEN-PEROXIDE - FORMATION OF OXYGEN AND SLOWING OF PEROXYNITRITE DECOMPOSITION [J].

ALVAREZ, B ;

DENICOLA, A ;

RADI, R .

CHEMICAL RESEARCH IN TOXICOLOGY, 1995, 8 (06) :859-864

[2] THE KINETICS OF THE OXIDATION OF L-ASCORBIC-ACID BY PEROXYNITRITE [J].

BARTLETT, D ;

CHURCH, DF ;

BOUNDS, PL ;

KOPPENOL, WH .

FREE RADICAL BIOLOGY AND MEDICINE, 1995, 18 (01) :85-92

[3] APPARENT HYDROXYL RADICAL PRODUCTION BY PEROXYNITRITE - IMPLICATIONS FOR ENDOTHELIAL INJURY FROM NITRIC-OXIDE AND SUPEROXIDE [J].

BECKMAN, JS ;

BECKMAN, TW ;

CHEN, J ;

MARSHALL, PA ;

FREEMAN, BA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (04) :1620-1624

[4] EXTENSIVE NITRATION OF PROTEIN TYROSINES IN HUMAN ATHEROSCLEROSIS DETECTED BY IMMUNOHISTOCHEMISTRY [J].

BECKMANN, JS ;

YE, YZ ;

ANDERSON, PG ;

CHEN, J ;

ACCAVITTI, MA ;

TARPEY, MM ;

WHITE, CR ;

BECKMAN, JS .

BIOLOGICAL CHEMISTRY HOPPE-SEYLER, 1994, 375 (02) :81-88

[5] KINETICS AND MECHANISM OF FORMATION AND DECAY OF PEROXYNITROUS ACID IN PERCHLORIC ACID SOLUTIONS [J].

BENTON, DJ ;

MOORE, P .

JOURNAL OF THE CHEMICAL SOCIETY A -INORGANIC PHYSICAL THEORETICAL, 1970, (18) :3179-&

[6] SENSITIVITY OF THE ESSENTIAL ZINC-THIOLATE MOIETY OF YEAST ALCOHOL-DEHYDROGENASE TO HYPOCHLORITE AND PEROXYNITRITE [J].

CROW, JP ;

BECKMAN, JS ;

MCCORD, JM .

BIOCHEMISTRY, 1995, 34 (11) :3544-3552

[7] SINGLET MOLECULAR-OXYGEN PRODUCTION IN THE REACTION OF PEROXYNITRITE WITH HYDROGEN-PEROXIDE [J].

DI MASCIO, P ;

BECHARA, EJH ;

MEDEIROS, MHG ;

BRIVIBA, K ;

SIES, H .

FEBS LETTERS, 1994, 355 (03) :287-289

[8]

FISCHER H, 1987, B SOC CHIM BELG, V96, P757

[9]

FLORIS R, 1993, EUR J BIOCHEM, V215, P767, DOI 10.1111/j.1432-1033.1993.tb18091.x

[10] FORMATION OF THIOCARBONYL COMPOUNDS IN THE REACTION OF EBSELEN OXIDE WITH THIOLS [J].

GLASS, RS ;

FAROOQUI, F ;

SABAHI, M ;

EHLER, KW .

JOURNAL OF ORGANIC CHEMISTRY, 1989, 54 (05) :1092-1097