HLA-A and CTGB33 polymorphisms and variation in IQ scores

被引：1

作者：

Jacomb, PA ^{[1
]}

Jorm, AF

Croft, L

Gao, X

Easteal, S

机构：

[1] Australian Natl Univ, Natl Hlth & Med Res Council, Psychiat Epidemiol Res Ctr, Canberra, ACT 0200, Australia

[2] Australian Natl Univ, John Curtin Sch Med Res, Human Genet Grp, Canberra, ACT 0200, Australia

来源：

PERSONALITY AND INDIVIDUAL DIFFERENCES | 1999年 / 26卷 / 05期

关键词：

D O I：

10.1016/S0191-8869(98)00177-9

中图分类号：

B84 [心理学];

学科分类号：

04 ; 0402 ;

摘要：

This study attempted to replicate findings of Plomin et al. (Plomin et al. (1991). DNA markers associated with high vs low IQ: The IQ quantitative trait loci (QTL) project, Behav, Genet., 24, 107-118) in which significant differences in allelic frequency at a locus in the HLA class I region and the triplet repeat, CTGB33 were found between low and high IQ subjects. The two IQ groups for our study were taken from a sample of elderly people whose IQ was assessed using a measure of intelligence that is highly resistant to the effects of ageing and dementia. The high IQ group had an average IQ of 125 while the lower group's;average IQ was 95. No difference was found in the allelic frequencies for any of the CTGB33 alleles or the HLA-A alleles. As there were a number of differences between this study and that of Plomin's group, this can only be viewed as a limited attempt at replication. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：795 / 799

页数：5

共 14 条

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