Study on the possible association of brain-derived neurotrophic factor polymorphism with the developmental course of symptoms of attention deficit and hyperactivity

被引：37

作者：

Bergman, Olle ^{[1
]}

Westberg, Lars

Lichtenstein, Paul ^{[2
]}

Eriksson, Elias

Larsson, Henrik ^{[2
,3
]}

机构：

[1] Univ Gothenburg, Dept Pharmacol, Inst Neurosci & Physiol, Sahlgrenska Acad, SE-40530 Gothenburg, Sweden

[2] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden

[3] Karolinska Inst, Ctr Neurodev Disorders, Stockholm, Sweden

来源：

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY | 2011年 / 14卷 / 10期

基金：

瑞典研究理事会;

关键词：

ADHD; BDNF; rs6265; Val(66)Met; FACTOR VAL66MET POLYMORPHISM; ACTIVITY-DEPENDENT SECRETION; FAMILY-BASED ASSOCIATION; COMMON VALINE ALLELE; FACTOR BDNF GENE; DEFICIT/HYPERACTIVITY DISORDER; DOPAMINERGIC-NEURONS; BIPOLAR DISORDER; ADHD SYMPTOMS; HUMAN-MEMORY;

D O I：

10.1017/S1461145711000502

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Several studies have, with conflicting results, investigated the relationship between the Val(66)Met polymorphism in brain-derived neurotrophic factor (BDNF) and attention deficit hyperactivity disorder (ADHD). We assessed longitudinal, quantitative phenotypes of hyperactivity-impulsivity and inattention in order to determine whether the Val(66)Met polymorphism is associated with age-specific and/or persistent symptoms of hyperactivity-impulsivity and/or inattention in a community-based cohort of 1236 Swedish individuals for which ADHD symptom data were collected when the participants were aged 8-9, 13-14 and 16-17 yr. The Met allele was associated with symptoms of ADHD at ages 8-9 and 13-14 yr. A multivariate regression analysis revealed that the observed effect of the Met allele on ADHD symptoms reflects an influence on persistent hyperactivity-impulsivity symptoms. The present findings support the hypothesis that BDNF is involved in the pathogenesis of ADHD. The results highlight the importance of distinguishing between hyperactivity-impulsivity and inattention, respectively, and demonstrate the value of using a longitudinal approach in genetic studies of ADHD symptoms.

引用

页码：1367 / 1376

页数：10

共 55 条

[1]

[Anonymous], 1994, AM PSYCHIATR ASSOC

[2] The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder:: association signals in DRD4, DAT1 and 16 other genes [J].

Brookes, K. ;

Xu, X. ;

Chen, W. ;

Zhou, K. ;

Neale, B. ;

Lowe, N. ;

Aneey, R. ;

Franke, B. ;

Gill, M. ;

Ebstein, R. ;

Buitelaar, J. ;

Sham, P. ;

Campbell, D. ;

Knight, J. ;

Andreou, P. ;

Altink, M. ;

Arnold, R. ;

Boer, F. ;

Buschgens, C. ;

Butler, L. ;

Christiansen, H. ;

Feldman, L. ;

Fleischman, K. ;

Fliers, E. ;

Howe-Forbes, R. ;

Goldfarb, A. ;

Heise, A. ;

Gabriels, I. ;

Korn-Lubetzki, I. ;

Marco, R. ;

Medad, S. ;

Minderaa, R. ;

Mulas, F. ;

Mueller, U. ;

Mulligan, A. ;

Rabin, K. ;

Rommelse, N. ;

Sethna, V. ;

Sorohan, J. ;

Uebel, H. ;

Psychogiou, L. ;

Weeks, A. ;

Barrett, R. ;

Craig, I. ;

Banaschewski, T. ;

Sonuga-Barke, E. J. S. ;

Eisenberg, J. ;

Kuntsi, J. ;

Manor, I. ;

McGuffin, P. .

MOLECULAR PSYCHIATRY, 2006, 11 (10) :934-953

[3] Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior [J].

Chen, Zhe-Yu ;

Jing, Deqiang ;

Bath, Kevin G. ;

Ieraci, Alessandro ;

Khan, Tanvir ;

Siao, Chia-Jen ;

Herrera, Daniel G. ;

Toth, Miklos ;

Yang, Chingwen ;

McEwen, Bruce S. ;

Hempstead, Barbara L. ;

Lee, Francis S. .

SCIENCE, 2006, 314 (5796) :140-143

[4] Variant brain-derived neurotrophic factor (BDNF) (Met66) alters the intracellular trafficking and activity-dependent secretion of wild-type BDNF in neurosecretory cells and cortical neurons [J].

Chen, ZY ;

Patel, PD ;

Sant, G ;

Meng, CX ;

Teng, KK ;

Hempstead, BL ;

Lee, FS .

JOURNAL OF NEUROSCIENCE, 2004, 24 (18) :4401-4411

[5] Environmental risk factors for attention-deficit hyperactivity disorder [J].

Das Banerjee, Tania ;

Middleton, Frank ;

Faraone, Stephen V. .

ACTA PAEDIATRICA, 2007, 96 (09) :1269-1274

[6] The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function [J].

Egan, MF ;

Kojima, M ;

Callicott, JH ;

Goldberg, TE ;

Kolachana, BS ;

Bertolino, A ;

Zaitsev, E ;

Gold, B ;

Goldman, D ;

Dean, M ;

Lu, B ;

Weinberger, DR .

CELL, 2003, 112 (02) :257-269

[7]

Ernst M, 1999, AM J PSYCHIAT, V156, P1209

[8]

Faraone SV, 2006, J CLIN PSYCHIAT, V67, P13

[9]

Faraone Stephen V, 2003, World Psychiatry, V2, P104

[10] Genetics of adult attention-deficit/hyperactivity disorder [J].

Faraone, SV .

PSYCHIATRIC CLINICS OF NORTH AMERICA, 2004, 27 (02) :303-+

← 1 2 3 4 5 6 →