A novel class of potent influenza virus inhibitors: Polysubstituted acylthiourea and its fused heterocycle derivatives

被引：81

作者：

Sun, CW ^{[1
]}

Huang, H ^{[1
]}

Feng, MQ ^{[1
]}

Shi, XL ^{[1
]}

Zhang, XD ^{[1
]}

Zhou, P ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, BioX Life Sci Res Ctr, Dept Life Sci & Technol, Shanghai 200030, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 01期

关键词：

influenza virus; inhibitor; acylthioureas; heterocycle; antiviral activity;

D O I：

10.1016/j.bmcl.2005.09.033

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of polysubstituted and fused heterocycle derivatives of acylthiourea was prepared and the biological activity against influenza virus was evaluated. Of the analogues that demonstrated IC(50)s < 0.1 mu M, acylthiourea derivatives 16 and 50 were further investigated as candidates with the most potential for future development. The SAR of these compounds are discussed and they represent a novel class of highly potent and selective inhibitors of influenza virus. (c) 2005 Published by Elsevier Ltd.

引用

页码：162 / 166

页数：5

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