Dietary phosphorus and blood pressure - International Study of Macro- and Micro-Nutrients and Blood Pressure

被引:84
作者
Elliott, Paul [1 ]
Kesteloot, Hugo [2 ]
Appel, Lawrence J. [3 ]
Dyer, Alan R. [4 ]
Ueshima, Hirotsugu [5 ]
Chan, Queenie [1 ]
Brown, Ian J. [1 ]
Zhao, Liancheng [6 ]
Stamler, Jeremiah [4 ]
机构
[1] Univ London Imperial Coll Sci Technol & Med, Fac Med, Dept Epidemiol & Publ Hlth, London W2 1PG, England
[2] Akad Ziekenhuis, Cent Lab, Louvain, Belgium
[3] Johns Hopkins Univ, Welch Ctr Prevent Epidemiol & Clin Res, Baltimore, MD USA
[4] Northwestern Univ, Dept Prevent Med, Feinberg Sch Med, Chicago, IL 60611 USA
[5] Shiga Univ Med Sci, Dept Hlth Sci, Otsu, Shiga 52021, Japan
[6] Chinese Acad Med Sci, Fu Wai Hosp & Cardiovasc Inst, Dept Epidemiol, Beijing 100037, Peoples R China
关键词
blood pressure; dietary phosphorus; calcium; magnesium; population study; primary prevention;
D O I
10.1161/HYPERTENSIONAHA.107.103747
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
Raised blood pressure is a leading cause of morbidity and mortality worldwide; improved nutritional approaches to population-wide prevention are required. Few data are available on dietary phosphorus and blood pressure and none are available on possible combined effects of phosphorus, magnesium, and calcium on blood pressure. The International Study of Macro- and Micro-Nutrients and Blood Pressure is a cross-sectional epidemiologic study of 4680 men and women ages 40 to 59 from 17 population samples in Japan, China, United Kingdom, and United States. Blood pressure was measured 8 times at 4 visits. Dietary intakes were obtained from four 24-hour recalls plus data on supplement use. Dietary phosphorus was inversely associated with blood pressure in a series of predefined multiple regression models, with the successive addition of potential confounders, both nondietary and dietary. Estimated blood pressure differences per 232 mg/1000 kcal (2 SD) of higher dietary phosphorus were -1.1 to -2.3 mm Hg systolic/-0.6 to -1.5 mm Hg diastolic (n = 4680) and -1.6 to -3.5 mm Hg systolic/-0.8 to -1.8 mm Hg diastolic for 2238 "nonintervened" individuals, ie, those without special diet/nutritional supplements or diagnosis/treatment for cardiovascular disease or diabetes. Dietary calcium and magnesium, correlated with phosphorus (partial r = 0.71 and r = 0.68), were inversely associated with blood pressure. Blood pressures were lower by 1.9 to 4.2 mm Hg systolic/1.2 to 2.4 mm Hg diastolic for people with intakes above versus below country-specific medians for all 3 of the minerals. These results indicate the potential for increased phosphorus/mineral intake to lower blood pressure as part of the recommendations for healthier eating patterns for the prevention and control of prehypertension and hypertension.
引用
收藏
页码:669 / 675
页数:7
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