The stage-specific function of gap junctions during tumourigenesis

被引:60
作者
Czyz, Jaroslaw [1 ]
机构
[1] Jagiellonian Univ, Fac Biochem Biophys & Biotechnol, Dept Cell Biol, PL-30378 Krakow, Poland
关键词
gap junctions; connexin; tumour; neoplasia; metastasis;
D O I
10.2478/s11658-007-0039-5
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Tumour development is a process resulting from the disturbance of various cellular functions including cell proliferation, adhesion and motility. While the role of these cell parameters in tumour promotion and progression has been widely recognized, the mechanisms that influence gap junctional coupling during tumorigenesis remain elusive. Neoplastic cells usually display decreased levels of connexin expression and/or gap junctional coupling. Thus, impaired intercellular communication via gap junctions may facilitate the release of a potentially neoplastic cell from the controlling regime of the surrounding tissue, leading to tumour promotion. However, recent data indicates that metastatic tumour cell lines are often characterized by relatively high levels of connexin expression and gap junctional coupling. This review outlines current knowledge on the role of connexins in tumorigenesis and the possible mechanisms of the interference of gap junctional coupling with the processes of tumour invasion and metastasis.
引用
收藏
页码:92 / 102
页数:11
相关论文
共 57 条
[1]   Normal cells control the growth of neighboring transformed cells independent of gap junctional communication and Src activity [J].
Alexander, DB ;
Ichikawa, H ;
Bechberger, JF ;
Valiunas, V ;
Ohki, M ;
Naus, CCG ;
Kunimoto, T ;
Tsuda, H ;
Miller, WT ;
Goldberg, GS .
CANCER RESEARCH, 2004, 64 (04) :1347-1358
[2]   Transfer of biologically important molecules between cells through gap junction channels [J].
Alexander, DB ;
Goldberg, GS .
CURRENT MEDICINAL CHEMISTRY, 2003, 10 (19) :2045-2058
[3]   Selective permeability of different connexin channels to the second messenger cyclic AMP [J].
Bedner, P ;
Niessen, H ;
Odermatt, B ;
Kretz, M ;
Willecke, K ;
Harz, H .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (10) :6673-6681
[4]  
Chambers AF, 1999, ONCOL RES, V11, P161
[5]  
CHEN SC, 1995, CELL GROWTH DIFFER, V6, P681
[6]   Flavonoid apigenin inhibits motility and invasiveness of carcinoma cells in vitro [J].
Czyz, J ;
Madeja, Z ;
Irmer, U ;
Korohoda, W ;
Hülser, DF .
INTERNATIONAL JOURNAL OF CANCER, 2005, 114 (01) :12-18
[7]  
Czyz J, 2004, ONCOL REP, V11, P739
[8]   Gap-junctional coupling measured by flow cytometry [J].
Czyz, J ;
Irmer, U ;
Schulz, G ;
Mindermann, A ;
Hülser, DF .
EXPERIMENTAL CELL RESEARCH, 2000, 255 (01) :40-46
[9]   Regulation of connexin-43-mediated growth inhibition by a phosphorylatable amino-acid is independent of gap junction-forming ability [J].
Dang, Xitong ;
Jeyaraman, Madhumathy ;
Kardami, Elissavet .
MOLECULAR AND CELLULAR BIOCHEMISTRY, 2006, 289 (1-2) :201-207
[10]   CYTOPLASMIC DYE TRANSFER BETWEEN METASTATIC TUMOR-CELLS AND VASCULAR ENDOTHELIUM [J].
ELSABBAN, ME ;
PAULI, BU .
JOURNAL OF CELL BIOLOGY, 1991, 115 (05) :1375-1382