Status and Prospects for Discovery and Verification of New Biomarkers of Cardiovascular Disease by Proteomics

被引：55

作者：

Gerszten, Robert E. ^{[1
,2
,3
]}

Asnani, Aarti

Carr, Steven A. ^{[3
]}

机构：

[1] Massachusetts Gen Hosp, Cardiovasc Res Ctr, Boston, MA 02114 USA

[2] Massachusetts Gen Hosp, Div Cardiol, Boston, MA 02114 USA

[3] Broad Inst MIT & Harvard, Cambridge, MA USA

来源：

CIRCULATION RESEARCH | 2011年 / 109卷 / 04期

基金：

美国国家卫生研究院;

关键词：

proteomics; biomarkers; mass spectrometry; PEPTIDE IMMUNOAFFINITY ENRICHMENT; HUMAN PLASMA PROTEOME; MASS-SPECTROMETRY; TROPONIN-I; MYOCARDIAL-INFARCTION; NATRIURETIC PEPTIDE; MULTIPLEXED ASSAYS; UNSTABLE ANGINA; PROTEINS; HEART;

D O I：

10.1161/CIRCRESAHA.110.225003

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Despite unmet needs for cardiovascular biomarkers, few new protein markers have been approved by the US Food and Drug Administration for the diagnosis or screening of cardiovascular diseases. Mass spectrometry-based proteomics technologies are capable of identifying hundreds to thousands of proteins in cells, tissues, and biofluids. Proteomics may therefore provide the opportunity to elucidate new biomarkers and pathways without a prior known association with cardiovascular disease; however, important obstacles remain. In this review, we focus on emerging techniques that may form a coherently integrated pipeline to overcome present limitations to both the discovery and validation processes. (Circ Res. 2011;109:463-474.)

引用

页码：463 / 474

页数：12

共 67 条

[1] Multi-site assessment of the precision and reproducibility of multiple reaction monitoring-based measurements of proteins in plasma [J].

Addona, Terri A. ;

Abbatiello, Susan E. ;

Schilling, Birgit ;

Skates, Steven J. ;

Mani, D. R. ;

Bunk, David M. ;

Spiegelman, Clifford H. ;

Zimmerman, Lisa J. ;

Ham, Amy-Joan L. ;

Keshishian, Hasmik ;

Hall, Steven C. ;

Allen, Simon ;

Blackman, Ronald K. ;

Borchers, Christoph H. ;

Buck, Charles ;

Cardasis, Helene L. ;

Cusack, Michael P. ;

Dodder, Nathan G. ;

Gibson, Bradford W. ;

Held, Jason M. ;

Hiltke, Tara ;

Jackson, Angela ;

Johansen, Eric B. ;

Kinsinger, Christopher R. ;

Li, Jing ;

Mesri, Mehdi ;

Neubert, Thomas A. ;

Niles, Richard K. ;

Pulsipher, Trenton C. ;

Ransohoff, David ;

Rodriguez, Henry ;

Rudnick, Paul A. ;

Smith, Derek ;

Tabb, David L. ;

Tegeler, Tony J. ;

Variyath, Asokan M. ;

Vega-Montoto, Lorenzo J. ;

Wahlander, Asa ;

Waldemarson, Sofia ;

Wang, Mu ;

Whiteaker, Jeffrey R. ;

Zhao, Lei ;

Anderson, N. Leigh ;

Fisher, Susan J. ;

Liebler, Daniel C. ;

Paulovich, Amanda G. ;

Regnier, Fred E. ;

Tempst, Paul ;

Carr, Steven A. .

NATURE BIOTECHNOLOGY, 2009, 27 (07) :633-U85

[2] Aptamer Microarray Mediated Capture and Mass Spectrometry Identification of Biomarker in Serum Samples [J].

Ahn, Ji-Young ;

Lee, Sang Wook ;

Kang, Hye Suk ;

Jo, Minjoung ;

Lee, Dong-ki ;

Laurell, Thomas ;

Kim, Soyoun .

JOURNAL OF PROTEOME RESEARCH, 2010, 9 (11) :5568-5573

[3] Mass spectrometric quantitation of peptides and proteins using stable isotope standards and capture by anti-peptide antibodies (SISCAPA) [J].

Anderson, NL ;

Anderson, NG ;

Haines, LR ;

Hardie, DB ;

Olafson, RW ;

Pearson, TW .

JOURNAL OF PROTEOME RESEARCH, 2004, 3 (02) :235-244

[4] The human plasma proteome - A nonredundant list developed by combination of four separate sources [J].

Anderson, NL ;

Polanski, M ;

Pieper, R ;

Gatlin, T ;

Tirumalai, RS ;

Conrads, TP ;

Veenstra, TD ;

Adkins, JN ;

Pounds, JG ;

Fagan, R ;

Lobley, A .

MOLECULAR & CELLULAR PROTEOMICS, 2004, 3 (04) :311-326

[5] EVALUATION OF A RAPID BEDSIDE ASSAY FOR DETECTION OF SERUM CARDIAC TROPONIN-T [J].

ANTMAN, EM ;

GRUDZIEN, C ;

SACKS, DB .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1995, 273 (16) :1279-1282

[6] Cardiac-specific troponin I levels to predict the risk of mortality in patients with acute coronary syndromes [J].

Antman, EM ;

Tanasijevic, MJ ;

Thompson, B ;

Schactman, M ;

McCabe, CH ;

Cannon, CP ;

Fischer, GA ;

Fung, AY ;

Thompson, C ;

Wybenga, D ;

Braunwald, E .

NEW ENGLAND JOURNAL OF MEDICINE, 1996, 335 (18) :1342-1349

[7] Mitochondrial PKCε and MAPK form signaling modules in the murine heart -: Enhanced mitochondrial PKCε-MAPK interactions and differential MAPK activation in PKCε-induced cardioprotection [J].

Baines, CP ;

Zhang, J ;

Wang, GW ;

Zheng, YT ;

Xiu, JX ;

Cardwell, EM ;

Bolli, R ;

Ping, P .

CIRCULATION RESEARCH, 2002, 90 (04) :390-397

[8] An LC-IMS-MS Platform Providing Increased Dynamic Range for High-Throughput Proteomic Studies [J].

Baker, Erin Shammel ;

Livesay, Eric A. ;

Orton, Daniel J. ;

Moore, Ronald J. ;

Danielson, William F., III ;

Prior, David C. ;

Ibrahim, Yehia M. ;

LaMarche, Brian L. ;

Mayampurath, Anoop M. ;

Schepmoes, Athena A. ;

Hopkins, Derek F. ;

Tang, Keqi ;

Smith, Richard D. ;

Belov, Mikhail E. .

JOURNAL OF PROTEOME RESEARCH, 2010, 9 (02) :997-1006

[9] Myeloperoxidase serum levels predict risk in patients with acute coronary syndromes [J].

Baldus, S ;

Heeschen, C ;

Meinertz, T ;

Zeiher, AM ;

Eiserich, JP ;

Münzel, T ;

Simoons, ML ;

Hamm, CW .

CIRCULATION, 2003, 108 (12) :1440-1445

[10]

BRAUNWALD E, 2002, ACC AHA GUIDELINE UP

← 1 2 3 4 5 6 7 →