Middle East respiratory syndrome coronavirus in children

被引:80
作者
Thabet, Farah [1 ]
Chehab, May [1 ]
Bafaqih, Hind [1 ]
AlMohaimeed, Sulaiman [1 ]
机构
[1] Prince Sultan Mil Med City, Dept Pediat, Div Pediat Intens Care, Riyadh 11159, Saudi Arabia
关键词
SAUDI-ARABIA; INFECTION;
D O I
10.15537/smj.2015.4.10243
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The Middle East respiratory syndrome (MERS) is a new human disease caused by a novel coronavirus (CoV). The disease is reported mainly in adults. Data in children are scarce. The disease caused by MERS-CoV in children presents with a wide range of clinical manifestations, and it is associated with a lower mortality rate compared with adults. Poor outcome is observed mainly in admitted patients with medical comorbidities. We report a new case of MERS-CoV infection in a 9-month-old child complicated by severe respiratory symptoms, multi-organ dysfunction, and death. We reviewed the literature in an attempt to characterize the mode of presentation, the risk factors, and outcome of MERS-CoV infection in the pediatric population.
引用
收藏
页码:484 / 486
页数:3
相关论文
共 10 条
[1]   Clinical Course and Outcomes of Critically Ill Patients With Middle East Respiratory Syndrome Coronavirus Infection [J].
Arabi, Yaseen M. ;
Arifi, Ahmed A. ;
Balkhy, Hanan H. ;
Najm, Hani ;
Aldawood, Abdulaziz S. ;
Ghabashi, Alaa ;
Hawa, Hassan ;
Alothman, Adel ;
Khaldi, Abdulaziz ;
Al Raiy, Basel .
ANNALS OF INTERNAL MEDICINE, 2014, 160 (06) :389-+
[2]   Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study [J].
Assiri, Abdullah ;
Al-Tawfiq, Jaffar A. ;
Al-Rabeeah, Abdullah A. ;
Al-Rabiah, Fahad A. ;
Al-Hajjar, Sami ;
Al-Barrak, Ali ;
Flemban, Hesham ;
Al-Nassir, Wafa N. ;
Balkhy, Hanan H. ;
Al-Hakeem, Rafat F. ;
Makhdoom, Hatem Q. ;
Zumla, Alimuddin I. ;
Memish, Ziad A. .
LANCET INFECTIOUS DISEASES, 2013, 13 (09) :752-761
[3]   Hospital Outbreak of Middle East Respiratory Syndrome Coronavirus [J].
Assiri, Abdullah ;
McGeer, Allison ;
Perl, Trish M. ;
Price, Connie S. ;
Al Rabeeah, Abdullah A. ;
Cummings, Derek A. T. ;
Alabdullatif, Zaki N. ;
Assad, Maher ;
Almulhim, Abdulmohsen ;
Makhdoom, Hatem ;
Madani, Hossam ;
Alhakeem, Rafat ;
Al-Tawfiq, Jaffar A. ;
Cotten, Matthew ;
Watson, Simon J. ;
Kellam, Paul ;
Zumla, Alimuddin I. ;
Memish, Ziad A. .
NEW ENGLAND JOURNAL OF MEDICINE, 2013, 369 (05) :407-416
[4]  
Denison MR, 2004, PEDIAT INFECT DIS, V11, P207
[5]   Middle East respiratory syndrome coronavirus not detected in children hospitalized with acute respiratory illness in Amman, Jordan, March 2010 to September 2012 [J].
Khuri-Bulos, N. ;
Payne, D. C. ;
Lu, X. ;
Erdman, D. ;
Wang, L. ;
Faouri, S. ;
Shehabi, A. ;
Johnson, M. ;
Becker, M. M. ;
Denison, M. R. ;
Williams, J. V. ;
Halasa, N. B. .
CLINICAL MICROBIOLOGY AND INFECTION, 2014, 20 (07) :678-682
[6]   Screening for Middle East respiratory syndrome coronavirus infection in hospital patients and their healthcare worker and family contacts: a prospective descriptive study [J].
Memish, Z. A. ;
Al-Tawfiq, J. A. ;
Makhdoom, H. Q. ;
Al-Rabeeah, A. A. ;
Assiri, A. ;
Alhakeem, R. F. ;
AlRabiah, F. A. ;
Al Hajjar, S. ;
Albarrak, A. ;
Flemban, H. ;
Balkhy, H. ;
Barry, M. ;
Alhassan, S. ;
Alsubaie, S. ;
Zumla, A. .
CLINICAL MICROBIOLOGY AND INFECTION, 2014, 20 (05) :469-474
[7]   Middle East Respiratory Syndrome Coronavirus Disease in Children [J].
Memish, Ziad A. ;
Al-Tawfiq, Jaffar A. ;
Assiri, Abdullah ;
AlRabiah, Fahad A. ;
Al Hajjar, Sami ;
Albarrak, Ali ;
Flemban, Hesham ;
Alhakeem, Rafat F. ;
Makhdoom, Hatem Q. ;
Alsubaie, Sarah ;
Al-Rabeeah, Abdullah A. .
PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2014, 33 (09) :904-906
[8]  
WHO, 2014, MIDDL E RESP SYNDR C
[9]  
World Health Organization, 2013, Middle East Respiratory Syndrome Coronavirus (MERSCoV)
[10]   Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia [J].
Zaki, Ali Moh ;
van Boheemen, Sander ;
Bestebroer, Theo M. ;
Osterhaus, Albert D. M. E. ;
Fouchier, Ron A. M. .
NEW ENGLAND JOURNAL OF MEDICINE, 2012, 367 (19) :1814-1820