Negative association between Catechol-O-methyltransferase (COMT) gene Val158Met polymorphism and persistent tardive dyskinesia in schizophrenia

被引：26

作者：

Lai, IC

Wang, YC

Lin, CC

Bai, YM

Liao, DL

Yu, SC

Lin, CY

Chen, JY

Liou, YJ

机构：

[1] Yuli Vet Hosp, Dept Psychiat, Yuli 981, Hualien, Taiwan

[2] Tzu Chi Univ, Inst Med Sci, Hualien, Taiwan

[3] Taipei Med Univ, Inst Clin Med, Taipei, Taiwan

[4] Natl Yang Ming Univ, Inst Publ Hlth, Taipei, Taiwan

[5] Pali PSychiat Ctr Hosp, Taipei, Taiwan

[6] Yuli Hosp, Dept Child Psychiat, Hualien, Taiwan

[7] Natl Yang Ming Univ, Inst Clin Med, Taipei 112, Taiwan

来源：

JOURNAL OF NEURAL TRANSMISSION | 2005年 / 112卷 / 08期

关键词：

Catechol-O-methyltransferase; COMT; tardive dyskinesia; polymorphism; association study; antipsychotics;

D O I：

10.1007/s00702-004-0252-6

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Chronic administration of typical antipsychotic agents, which mainly act on the dopamine receptors, implicates a role of dopamine system on the susceptibility of tardive dyskinesia (TD). In the present study, the association between a functional Val158Met polymorphism of Catechol-O-methyltransferase (COMT) gene and TD occurrence and TD severity was investigated in 299 Chinese schizophrenic patients with long-term antipsychotic treatment (TD: 166, non-TD: 133). After adjusting the effects of confounding factors, there was no significant association between COMT genotype and TD occurrence (p=0.367). Among TD patients, we found no significant correlation between COMT genotypes and the total scores of abnormal involuntary movement scale (AIMS) (p=0.629). We concluded that this COMT polymorphism might not play a major role in the susceptibility of TD nor on the severity of TD.

引用

页码：1107 / 1113

页数：7

共 17 条

[1] Neurotoxicity associated with neuroleptic-induced oral dyskinesias in rats - Implications for tardive dyskinesia? [J].