Umbilical cord blood transplantation in adults using myeloablative and nonmyeloablative preparative regimens

被引：53

作者：

Koh, LP ^{[1
]}

Chao, NF ^{[1
]}

机构：

[1] Duke Univ, Med Ctr, Adult Bone Marrow Transplant Program, Durham, NC 27710 USA

来源：

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION | 2004年 / 10卷 / 01期

关键词：

umbilical cord blood transplantation hematopoietic stem cell transplantation; nonmyeloablative preparative regimen;

D O I：

10.1016/j.bbmt.2003.09.009

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Unrelated umbilical cord blood (UCB) transplantation has recently been explored in an increasing number of adult patients. The relative case of procurement and the lower-than-anticipated risk of severe acute graft-versus-host disease has made UCB transplantation an appealing alternative to bone marrow-derived hematopoietic stem cells. The use of reduced-intensity or nonmyeloablative preparative regimens to allow engraftment of UCB broadens the scope of patients who may benefit from allogeneic immunotherapy, including elderly and medically infirm patients with no matched sibling donor. This review summarizes the available data on the use of UCB as an alternative source of hematopoietic stem cell transplantation in adult patients. (C) 2004 American Society for Blood and Marrow Transplantation.

引用

页码：1 / 22

页数：22

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