Biological roles of L-carnitine in perinatal metabolism

被引：56

作者：

Arenas, J ^{[1
]}

Rubio, JC ^{[1
]}

Martín, MA ^{[1
]}

Campos, Y ^{[1
]}

机构：

[1] Hosp Univ 12 Octubre, Ctr Invest, Madrid 28041, Spain

来源：

EARLY HUMAN DEVELOPMENT | 1998年 / 53卷

关键词：

L-carnitine; beta oxidation; fetal maturation; energy metabolism; perinatal metabolism; antioxidant;

D O I：

10.1016/S0378-3782(98)00064-4

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Carnitine performs a crucial role in the energy supply of tissues during fetal life and in the neonatal period by controlling the influx of fatty acids into mitochondria. Carnitine also facilitates the oxidation of pyruvate and branched chain amino acids, and contributes to the protection of cells from the deleterious actions of acyl CoAs. Carnitine further acts as a secondary antioxidant, favouring fatty acid replacement within previously oxidatively damaged membrane phospholipids. Availability of L-carnitine is essential in the developing fetus for processes underlying fetal maturation. L-carnitine is also essential for development of hepatic ketone synthesis, a central pathway for neonatal energy metabolism Ketone bodies inhibit the oxidation of both glucose and lactate, sparing these metabolic substrates for biosynthetic functions. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：S43 / S50

页数：8

共 30 条

[1]

[Anonymous], L CARNITINE ITS ROLE

[2]

ARDUINI A, 1992, J BIOL CHEM, V267, P12673

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