From the decidual cell Internet: Trophoblast-recognizing T cells

被引:37
作者
Arck, P
Dietl, J
Clark, D
机构
[1] Humboldt Univ, Charite, Med Klin Psychosomat, D-13353 Berlin, Germany
[2] Univ Wurzburg, Dept Obstet & Gynecol, D-97080 Wurzburg, Germany
[3] McMaster Univ, Dept Med, Hamilton, ON L7N 3Z5, Canada
[4] McMaster Univ, Dept Obstet & Gynocol, Hamilton, ON L7N 3Z5, Canada
关键词
D O I
10.1095/biolreprod60.2.227
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
The mammalian fetus has been perceived, paradoxically, as a successful allograft, a successful tumor, and a successful parasite. Success depends on fetal trophoblast cells, which form the interface with the mother. The maternal immune system is involved in the success of pregnancy and in its failure. The discovery that maternal gamma delta T cells may recognize and react to the fetal trophoblast and the definition of a vascular mechanism whereby their Th1 and Th2/3-type cytokines may abort embryos replaces confusion and debate with a new and simple clarity that enables further research.
引用
收藏
页码:227 / 233
页数:7
相关论文
共 96 条
  • [1] ALLEN WR, 1982, J REPROD FERTIL, P57
  • [2] PRECONCEPTIONAL NATURAL-KILLER-CELL ACTIVITY AS A PREDICTOR OF MISCARRIAGE
    AOKI, K
    KAJIURA, S
    MATSUMOTO, Y
    OGASAWARA, M
    OKADA, S
    YAGAMI, Y
    GLEICHER, N
    [J]. LANCET, 1995, 345 (8961): : 1340 - 1342
  • [3] Inhibition of immunoprotective CD8(+) T cells as a basis for stress-triggered substance P-mediated abortion in mice
    Arck, PC
    Merali, F
    Chaouat, G
    Clark, DA
    [J]. CELLULAR IMMUNOLOGY, 1996, 171 (02) : 226 - 230
  • [4] STRESS-INDUCED MURINE ABORTION ASSOCIATED WITH SUBSTANCE BETA-DEPENDENT ALTERATION IN CYTOKINES IN MATERNAL UTERINE DECIDUA
    ARCK, PC
    MERALI, FS
    STANISZ, AM
    STEAD, RH
    CHAOUAT, G
    MANUEL, J
    CLARK, DA
    [J]. BIOLOGY OF REPRODUCTION, 1995, 53 (04) : 814 - 819
  • [5] Arck PC, 1997, AM J REPROD IMMUNOL, V37, P87
  • [6] Arck PC, 1997, AM J REPROD IMMUNOL, V37, P492
  • [7] ARCK PC, 1998, AM J REPROD IMMUNOL, V39
  • [8] Baines MG, 1997, AM J REPROD IMMUNOL, V37, P471
  • [9] Baines MG, 1996, AM J REPROD IMMUNOL, V35, P34, DOI 10.1111/j.1600-0897.1996.tb00006.x
  • [10] HUMORAL IMMUNE-RESPONSES IN MURINE PREGNANCY .5. RELATIONSHIP TO THE DIFFERENTIAL IMMUNOGENICITY OF PLACENTAL AND FETAL TISSUES
    BELL, SC
    BILLINGTON, WD
    [J]. JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 1986, 9 (04) : 289 - 302