Detection of hepatitis B surface antigen mutants and their integration in human hepatocellular carcinoma

被引：20

作者：

Oon, CJ ^{[1
]}

Chen, WN ^{[1
]}

Zhao, Y ^{[1
]}

Teng, SW ^{[1
]}

Leong, AL ^{[1
]}

机构：

[1] Singapore Gen Hosp, Minist Hlth, Dept Clin Res, Ransome Res Lab, Singapore 169608, Singapore

来源：

CANCER LETTERS | 1999年 / 136卷 / 01期

基金：

英国医学研究理事会;

关键词：

hepatitis B virus surface mutant; glycine-145-arginine; methionine-133-threonine; hepatocellular carcinoma; integration;

D O I：

10.1016/S0304-3835(98)00314-0

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Vaccine escape hepatitis B virus surface antigen (HBsAg) mutants are capable of independent replication and have been implicated in acute hepatitis. We now report the detection of these mutants with changes at various positions of the antigenic 'a' determinant in human hepatocellular carcinoma (HCC). Southern blot analysis indicated that the HBsAg mutant with the Glycine to Arginine change at position 145 was integrated in HCC, whereas those with a Threonine at position 133 instead of a Methionine were identified in the serum of aggressive HCC. Further studies on HBsAg mutants in HCC should provide new insights on their involvement in the hepatocarcinogenesis. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.

引用

页码：95 / 99

页数：5

共 13 条

[1] PRESENCE OF INTEGRATED HEPATITIS-B VIRUS-DNA SEQUENCES IN CELLULAR DNA OF HUMAN HEPATOCELLULAR-CARCINOMA [J].

BRECHOT, C ;

POURCEL, C ;

LOUISE, A ;

RAIN, B ;

TIOLLAIS, P .

NATURE, 1980, 286 (5772) :533-535

[2] VACCINE-INDUCED ESCAPE MUTANT OF HEPATITIS-B VIRUS [J].

CARMAN, WF ;

ZANETTI, AR ;

KARAYIANNIS, P ;

WATERS, J ;

MANZILLO, G ;

TANZI, E ;

ZUCKERMAN, AJ ;

THOMAS, HC .

LANCET, 1990, 336 (8711) :325-329

[3] FULMINANT REACTIVATION OF HEPATITIS-B DUE TO ENVELOPE PROTEIN MUTANT THAT ESCAPED DETECTION BY MONOCLONAL HBSAG ELISA [J].

CARMAN, WF ;

KORULA, J ;

WALLACE, L ;

MACPHEE, R ;

MIMMS, L ;

DECKER, R .

LANCET, 1995, 345 (8962) :1406-1407

[4]

CHEN WN, 1994, J BIOL CHEM, V269, P32394

[5] Surface gene mutants of hepatitis B virus in infants who develop acute or chronic infections despite immunoprophylaxis [J].

Hsu, HY ;

Chang, MH ;

Ni, YH ;

Lin, HH ;

Wang, SM ;

Chen, DS .

HEPATOLOGY, 1997, 26 (03) :786-791

[6]

Jakubczak JL, 1997, CANCER RES, V57, P3606

[7]

LAU JYN, 1993, LANCET, V342, P1335

[8] Infectivity and pathogenicity in chimpanzees of a surface gene mutant of hepatitis B virus that emerged in a vaccinated infant [J].

Ogata, N ;

Zanetti, AR ;

Yu, MS ;

Miller, RH ;

Purcell, RH .

JOURNAL OF INFECTIOUS DISEASES, 1997, 175 (03) :511-523

[9] MUTATIONS WITHIN THE S GENE OF HEPATITIS-B VIRUS TRANSMITTED FROM MOTHERS TO BABIES IMMUNIZED WITH HEPATITIS-B IMMUNE GLOBULIN AND VACCINE [J].

OKAMOTO, H ;

YANO, K ;

NOZAKI, Y ;

MATSUI, A ;

MIYAZAKI, H ;

YAMAMOTO, K ;

TSUDA, F ;

MACHIDA, A ;

MISHIRO, S .

PEDIATRIC RESEARCH, 1992, 32 (03) :264-268

[10]

OKAMOTO H, 1987, JPN J EXP MED, V57, P231

← 1 2 →