Staphylokinase: a potent, uniquely fibrin-selective thrombolytic agent

被引：135

作者：

Collen, D

机构：

[1] Catholic Univ Louvain, Ctr Mol & Vasc Biol, B-3000 Louvain, Belgium

[2] Katholieke Univ Leuven VIB, Ctr Transgene Technol & Gene, B-3001 Leuven, Belgium

来源：

NATURE MEDICINE | 1998年 / 4卷 / 03期

关键词：

D O I：

10.1038/nm0398-279

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Thrombosis, the blockage of blood vessels with dots, can lead to acute myocardial infarction and ischemia stroke both leading causes of death. Other than surgical interventions to remove or by pass the blockage or the generation of collateral vessels to provide a new blood supply, the only treatment available is the administration of thrombolytic agents to dissolve the blood clot. In this review, Desire Callen considers the properties and characteristics of staphylokinase that make it the thrombolytic agent of choice.

引用

页码：279 / 284

页数：6

共 46 条

[1] CLONING AND EXPRESSION IN ESCHERICHIA-COLI, BACILLUS-SUBTILIS, AND STREPTOCOCCUS-SANGUIS OF A GENE FOR STAPHYLOKINASE - A BACTERIAL PLASMINOGEN-ACTIVATOR
BEHNKE, D
GERLACH, D
[J]. MOLECULAR & GENERAL GENETICS, 1987, 210 (03): : 528 - 534
[2] One-year results from the global utilization of streptokinase and TPA for occluded coronary arteries (GUSTO-I) trial
Califf, RM
White, HD
VandeWerf, EV
Sadowski, Z
Armstrong, PW
Vahanian, A
Simoons, ML
Simes, RJ
Lee, KL
Topol, EJ
[J]. CIRCULATION, 1996, 94 (06) : 1233 - 1238
[3] Selection of thrombolytic therapy for individual patients: Development of a clinical model
Califf, RM
Woodlief, LH
Harrell, FE
Lee, KL
White, HD
Guerci, A
Barbash, GI
Simes, RJ
Weaver, WDD
Simoons, ML
Topol, EJ
[J]. AMERICAN HEART JOURNAL, 1997, 133 (06) : 630 - 639
[4] STREPTOCOCCAL FIBRINOLYSIS - A PROTEOLYTIC REACTION DUE TO A SERUM ENZYME ACTIVATED BY STREPTOCOCCAL FIBRINOLYSIN
CHRISTENSEN, LR
[J]. JOURNAL OF GENERAL PHYSIOLOGY, 1945, 28 (04) : 363 - 383
[5] Fibrin-selective thrombolytic therapy for acute myocardial infarction
Collen, D
[J]. CIRCULATION, 1996, 93 (05) : 857 - 865
[6] PRIMARY STRUCTURE AND GENE STRUCTURE OF STAPHYLOKINASE
COLLEN, D
ZHAO, ZA
HOLVOET, P
MARYNEN, P
[J]. FIBRINOLYSIS, 1992, 6 (04) : 226 - 231
[7] Collen D, 1997, CIRCULATION, V95, P463
[8] Collen D, 1997, CIRCULATION, V95, P455
[9] Recombinant staphylokinase variants with altered immunoreactivity .1. Thrombolytic properties and antibody induction
Collen, D
Moreau, H
Stockx, L
Vanderschueren, S
[J]. CIRCULATION, 1996, 94 (02) : 207 - 216
[10] MECHANISMS OF ACTIVATION OF MAMMALIAN PLASMA FIBRINOLYTIC SYSTEMS WITH STREPTOKINASE AND WITH RECOMBINANT STAPHYLOKINASE
COLLEN, D
VANHOEF, B
SCHLOTT, B
HARTMANN, M
GUHRS, KH
LIJNEN, HR
[J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1993, 216 (01): : 307 - 314

← 1 2 3 4 5 →