Common chromosome aberrations in the proximal type of epithelioid sarcoma

被引：18

作者：

Debiec-Rychter, M ^{[1
]}

Sciot, R

Hagemeijer, A

机构：

[1] Katholieke Univ Leuven, Ctr Human Genet, Louvain, Belgium

[2] Katholieke Univ Leuven, Dept Pathol, Louvain, Belgium

来源：

CANCER GENETICS AND CYTOGENETICS | 2000年 / 123卷 / 02期

关键词：

D O I：

10.1016/S0165-4608(00)00320-4

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A new case of the proximal type of epithelioid sarcoma with a complex karyotype 70-98 <4N>,XX, -X, -X,+5,i(5)(q10), +7,del(7)(q31),i(8)(q10)x3 similar to4,del(12)(p13) der(18)ins(18;?) (q11;?)del(18)(p11). ish der(18)ins(18;X)del(18)(p11)(wcp18+,wcpX+),+20,+20,dmin [cp9] is described. Both, dual-color FISH using probes specific for OATLI1/OATL2 genes and RT-PCR analysis excluded the presence of t(X;18), typical for synovial sarcoma. Our case together with the previously published ones suggest that the presence of i(8)(q10), losses of 12p and 18p together with the gain of chromosome 20 may represent a common cytogenetic aberrations in the proximal type of epithelioid sarcoma. (C) 2000 Elsevier Science Inc. An rights reserved.

引用

页码：133 / 136

页数：4

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