Cladocalol, a pentacyclic 28-nor-triterpene from Eucalyptus cladocalyx with cytotoxic activity

被引：42

作者：

Benyahia, S

Benayache, S

Benayache, F

León, F

Quintana, J

López, M

Hernández, JC

Estévez, F

Bermejo, J

机构：

[1] Univ La Laguna, Inst Bioorgan Antonio Gonzalez, Inst Prod Nat & Agrobiol, CSIC, Tenerife 38206, Spain

[2] Inst Canario Invest Canc ICIC, Tenerife, Spain

[3] Univ Palmas Gran Canaria, Ctr Ciencias Salud, Dept Bioquim, Las Palmas Gran Canaria 35016, Spain

来源：

PHYTOCHEMISTRY | 2005年 / 66卷 / 06期

关键词：

Eucalyptus cladocalyx; Myrtaceae; pentacyclic triterpenes; sterol; flavonoid; single-crystal X-ray analysis; cytotoxic;

D O I：

10.1016/j.phytochem.2004.12.018

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A formylated triterpene named cladocalol has been isolated from the leaves of Eucalyptus cladocalyx, together with ursulolactone acetate, ursolic acid, 3 beta-acetate-12,20(29)-lupadien-28-oic acid, beta-sitosterol and the known flavonoid eucalyptine. Their structures were mainly established by extensive NMR studies (H-1 NMR, C-13 NMR, DEPT, H-1-H-1 COSY, HSQC, HMBC) and mass spectroscopy as well as by X-ray crystallographic analysis. In this paper, we report on the cytotoxic effect induced by cladocalol and its derivatives on the myeloid leukemia cell line HL-60. (c) 2004 Elsevier Ltd. All rights reserved.

引用

页码：627 / 632

页数：6

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