Desperately seeking subunits:: are native 5-HT3 receptors really homomeric complexes?

被引:58
作者
Fletcher, S [1 ]
Barnes, NM [1 ]
机构
[1] Univ Birmingham, Sch Med, Dept Pharmacol, Birmingham B15 2TT, W Midlands, England
基金
英国惠康基金;
关键词
D O I
10.1016/S0165-6147(98)01210-3
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The 5-HT3 receptor complex is a ligand-gated ion channel, and is therefore likely to comprise multiple subunits in common with other members of this superfamily. To date, however, only one 5-MT3 receptor subunit, plus an alternatively spliced variant, have been identified. In this article, Stephanie Fletcher and Nicholas Barnes review some of the extensive data in the literature that suggest the presence of other 5-HT3 receptor subunits, This is particularly relevant given the recent demonstration that the 5-HT3 receptor purified from pig brain contains a non-5-HT3A-like protein(s).
引用
收藏
页码:212 / 215
页数:4
相关论文
共 32 条
  • [1] Comparison of [H-3]YM060 binding to native and cloned rat 5-HT3 receptors
    Akuzawa, S
    Miyake, A
    Miyata, K
    Fukutomi, H
    [J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1996, 296 (02) : 227 - 230
  • [2] BOESS FG, 1995, J NEUROCHEM, V64, P1401
  • [3] MOLECULAR-PROPERTIES OF 5-HYDROXYTRYPTAMINE3 RECEPTOR-TYPE BINDING-SITES PURIFIED FROM NG108-15 CELLS
    BOESS, FG
    LUMMIS, SCR
    MARTIN, IL
    [J]. JOURNAL OF NEUROCHEMISTRY, 1992, 59 (05) : 1692 - 1701
  • [4] PHARMACOLOGICAL CHARACTERIZATION OF 5-HYDROXYTRYPTAMINE(3) RECEPTORS IN MURINE BRAIN AND ILEUM USING THE NOVEL RADIOLIGAND [H-3] RS-42358-197 - EVIDENCE FOR RECEPTOR HETEROGENEITY
    BONHAUS, DW
    WONG, EHF
    STEFANICH, E
    KUNYSZ, EA
    EGLEN, RM
    [J]. JOURNAL OF NEUROCHEMISTRY, 1993, 61 (05) : 1927 - 1932
  • [5] 5-HT3 RECEPTORS ARE MEMBRANE ION CHANNELS
    DERKACH, V
    SURPRENANT, A
    NORTH, RA
    [J]. NATURE, 1989, 339 (6227) : 706 - 709
  • [6] PHARMACOLOGICAL CHARACTERIZATION OF THE APPARENT SPLICE VARIANTS OF THE MURINE 5-HT3, R-A SUBUNIT EXPRESSED IN XENOPUS-LAEVIS OOCYTES
    DOWNIE, DL
    HOPE, AG
    LAMBERT, JJ
    PETERS, JA
    BLACKBURN, TP
    JONES, BJ
    [J]. NEUROPHARMACOLOGY, 1994, 33 (3-4) : 473 - 482
  • [7] Purification of 5-hydroxytryptamine(3) receptors from porcine brain
    Fletcher, S
    Barnes, NM
    [J]. BRITISH JOURNAL OF PHARMACOLOGY, 1997, 122 (04) : 655 - 662
  • [8] THE POSTSYNAPTIC 43K PROTEIN CLUSTERS MUSCLE NICOTINIC ACETYLCHOLINE-RECEPTORS IN XENOPUS OOCYTES
    FROEHNER, SC
    LUETJE, CW
    SCOTLAND, PB
    PATRICK, J
    [J]. NEURON, 1990, 5 (04) : 403 - 410
  • [9] AN ELECTROPHYSIOLOGICAL INVESTIGATION OF THE PROPERTIES OF A MURINE RECOMBINANT 5-HT3 RECEPTOR STABLY EXPRESSED IN HEK-293 CELLS
    GILL, CH
    PETERS, JA
    LAMBERT, JJ
    [J]. BRITISH JOURNAL OF PHARMACOLOGY, 1995, 114 (06) : 1211 - 1221
  • [10] HARGREAVES AC, 1994, MOL PHARMACOL, V46, P1120