ppGpp regulation of RpoS degradation via anti-adaptor protein IraP

被引：103

作者：

Bougdour, Alexandre ^{[1
]}

Gottesman, Susan ^{[1
]}

机构：

[1] NCI, Mol Biol Lab, NIH, Bethesda, MD 20892 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2007年 / 104卷 / 31期

关键词：

phosphate starvation; sigma(38); SpoT;

D O I：

10.1073/pnas.0705561104

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

lraP is a small protein that interferes with the delivery of os (RpoS) to the ClpXP protease by blocking the action of RssB, an adaptor protein for os degradation. lraP was previously shown to mediate stabilization of os during phosphate starvation. Here, we show that iraP is transcribed in response to phosphate starvation; this response is mediated by ppGpp. The iraP promoter is positively regulated by ppGpp, dependent on the discriminator region of the iraP promoter. Sensing of phosphate starvation requires SpoT but not RelA. The results demonstrate a target for positive regulation by ppGpp and suggest that the cell use of ppGpp to mediate a variety of starvation responses operates in part by modulating sigma(s) levels.

引用

页码：12896 / 12901

页数：6

共 44 条

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