Synthesis and biological evaluation of DNA targeting flexible side-chain substituted β-carboline derivatives

被引：115

作者：

Xiao, SL ^{[1
]}

Lin, W ^{[1
]}

Wang, C ^{[1
]}

Yang, M ^{[1
]}

机构：

[1] Peking Univ, Natl Res Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 04期

基金：

中国国家自然科学基金;

关键词：

D O I：

10.1016/S0960-894X(00)00679-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 3-substituted-beta -carboline derivatives was synthesized from L-tryptophan. The intercalating binding mode of these compounds with DNA, the effects of the flexible alkylamine side chain on the intercalating ability and their antitumor activity were studied, which agreed well with the molecular modeling results. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：437 / 441

页数：5

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